Our Collaborative Research Center (CRC) includes 20 subprojects that contribute to four project areas with different focal points.

Research area A investigates the molecular and cellular determinants of neural resources, through the exploration of synaptic connections and small neural networks at the microscopic level. Research area B focuses on neural resources at the mesoscopic level, i.e., through the connectivity across brain areas. Research area C is dedicated to the macroscopic level and investigates, for example, how neural resources are assigned to tasks. The service projects (Z) support all subprojects with specialized methodology and know-how – from microscopic visualization of active synapses to tau imaging in “super agers”.

Molecular & cellular determinants of neural resources

Research area A

A01


NMDA receptor-dependent prefrontal circuits critical for cognitive flexibility

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A02


Shaping neuronal engram ensembles through excitation-transcription coupling

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A03


Neural circuits underlying behaviour-dependent brain state transitions: Resource allocation for optimized memory processing in health and disease

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A04


Cognitive enhancement by the anti- ageing hormone Klotho – from molecular mechanisms to interventions

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A05


Extracellular matrix integrity as neural resource of memory precision and cognitive flexibility

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A07


Mobilising cognitive resource through orexinergic modulation of hippocampal circuits

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NEW

A09


Mnemonic resources of the mammillary body

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Meso-scale determinants of neural resources

Research area B

B02


Mobilizing reserve in episodic memory in individuals with Alzheimer`s disease pathology

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B03



From Alzheimer’s Disease to SuperAgeing: A Cross-Species Study on Grid Cells as a central resource for Memory and Navigation

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B04



Synaptic density, MTL circuit function and microvascular plasticity in aging and SuperAging

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B05



Mobilisation of attentional resources in multiple object and feaure tracking: training and perturbation of circuits

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B06



Deployment of neural resources for temporal attention across the senses

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New
B07


Circuit-specific improvements of mnemonic discrimination in the rodent and human entorhino-hippocampal subnetworks
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Macro-scale principles of neural resources and resource allocation

Research area C

C01


Embodied cognitive reserve in the cortico-subcortical premotor network

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C03



Parallel planning as a resource for human skill learning and memory

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C04



Restoring neural resources perturbed by sleep deprivation

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C05


Wavelike dynamics in neocortical networks for cognitive control

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Scientific Service
Projects

Research area Z

Z01


Functional neural circuit analysis of the rodent brain

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Z02


Mesoscopic imaging of human brain structure, function and neurofluids
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Z03



Human molecular imaging ageing and SuperAgeing cohort

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Experts



Clinical Experts

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