{"id":37961,"date":"2025-11-24T10:00:00","date_gmt":"2025-11-24T09:00:00","guid":{"rendered":"https:\/\/sfb1436.de\/?p=29402"},"modified":"2026-07-24T11:14:26","modified_gmt":"2026-07-24T09:14:26","slug":"dr-therpurakal-zu-gast-im-sfb-1436","status":"publish","type":"post","link":"https:\/\/sfb1436.de\/de\/dr-therpurakal-zu-gast-im-sfb-1436\/","title":{"rendered":"Vortragsank\u00fcndigung: Dr. Therpurakal zu Gast im SFB 1436"},"content":{"rendered":"\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-7387b849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<figure class=\"wp-block-image size-full is-resized\"><img decoding=\"async\" src=\"https:\/\/sfb1436.de\/wp-content\/uploads\/2025\/10\/Invitation_Therpurakal.png\" alt=\"Invitation_ Rajeevan Narayanan Therpurakal\" class=\"wp-image-29063\" style=\"aspect-ratio:0.7070363086958608;width:168px;height:auto\"\/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<p class=\"wp-block-paragraph\">Am 28.11.2025 ist Dr. Rajeevan Narayanan Therpurakal von der Universit\u00e4tsklinik D\u00fcsseldorf und der Heinrich-Heine-Universit\u00e4t D\u00fcsseldorf zu Gast in unserer SFB-Vortragsreihe.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Wann: Freitag, den 28.11.2025 um 11:00 Uhr<br>Wo: DZNE, Raum 121<br>Titel: Bridging Basic Orexin Circuitry and MS Models: L6 OX2R as a Therapeutic Entry Point<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-7387b849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"wp-block-paragraph\"><em>Abstract: Bridging Basic Orexin Circuitry and MS Models: L6 OX2R as a Therapeutic Entry Point<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Background. Multiple sclerosis (MS) is a chronic demyelinating disease affecting the brain and spinal cord. Experimental autoimmune encephalomyelitis (EAE) is a well-established mouse model that mimics key features of MS. The orexin (hypocretin) neuropeptide system\u2014mainly known for regulating arousal\u2014has emerging roles in neuroimmune modulation. Orexins communicate through two G protein\u2013coupled receptors: orexin receptor-1 (OX1R) and orexin receptor-2 (OX2R). Recent research identifies a subset of cortical layer-6 (L6) neurons that express OX2R and can \u201cgate\u201d cortical network states.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Our findings. In EAE, we observe an early increase in neuronal network activity. Rather than being uniformly harmful, we hypothesize that modest, orexin-tuned activity reorganizes rhythms to promote remyelination. Following EAE induction, clinical outcomes diverge by age despite identical genotypes and immunization protocols: older mice show significantly higher clinical scores than younger cohorts. Orexin levels inversely correlate with clinical severity\u2014higher orexin is linked to lower scores. At the receptor level, we detect an age-dependent downregulation of OX1R, with no change in OX2R.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Conclusion. The combination of early hyperexcitability and improved outcomes in animals with higher orexin supports a neuroimmune-modulatory role for the orexinergic system. These findings connect fundamental orexin circuit biology to MS models and highlight L6 OX2R as a promising therapeutic target.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Abbreviations: MS, multiple sclerosis; EAE, experimental autoimmune encephalomyelitis; L6, cortical layer 6; OX1R\/OX2R, orexin receptor-1\/-2.<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Am 28.11.2025 ist Dr. Rajeevan Narayanan Therpurakal von der Universit\u00e4tsklinik D\u00fcsseldorf und der Heinrich-Heine-Universit\u00e4t D\u00fcsseldorf zu Gast in unserer SFB-Vortragsreihe. Wann: Freitag, den 28.11.2025 um 11:00 UhrWo: DZNE, Raum 121Titel: Bridging Basic Orexin Circuitry and MS Models: L6 OX2R as a Therapeutic Entry Point Abstract: Bridging Basic Orexin Circuitry and MS Models: L6 OX2R as [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":17101,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[288,281,219,220],"tags":[566,331,372,1814,1778,330,1676,478],"class_list":["post-37961","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-all-news-and-events-de","category-alle-news-und-events","category-events-de","category-news-de","tag-crc-1436-de","tag-magdeburg","tag-neurowissenschaften","tag-neurowissenschaften-2","tag-rajeevan-narayanan-therpurakal","tag-sfb-1436","tag-universitaetsklinik-duesseldorf","tag-vortrag"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.2 - 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