{"id":7080,"date":"2022-02-11T14:48:35","date_gmt":"2022-02-11T13:48:35","guid":{"rendered":"https:\/\/sfb1436.de\/menue-1\/extracellular-matrix-integrity-as-neural-resource-of-cognitive-flexibility\/"},"modified":"2025-12-12T04:08:18","modified_gmt":"2025-12-12T03:08:18","slug":"integritaet-der-extrazellulaermatrix-als-neurale-ressource-fuer-gedaechtnis-praezision-und-kognitive-flexibilitaet","status":"publish","type":"page","link":"https:\/\/sfb1436.de\/de\/projekte\/integritaet-der-extrazellulaermatrix-als-neurale-ressource-fuer-gedaechtnis-praezision-und-kognitive-flexibilitaet\/","title":{"rendered":"A05 &#8211; Integrit\u00e4t der Extrazellul\u00e4rmatrix als neurale Ressource f\u00fcr Ged\u00e4chtnis-Pr\u00e4zision und kognitive Flexibilit\u00e4t"},"content":{"rendered":"\n<div class=\"wp-block-uagb-section uagb-section__wrap uagb-section__background-color uagb-block-1ea1d236 badge-title\"><div class=\"uagb-section__overlay\"><\/div><div class=\"uagb-section__inner-wrap\">\n<p class=\"has-text-align-center wp-block-paragraph\">A05<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group alignwide has-white-background-color has-background is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-columns are-vertically-aligned-center is-layout-flex wp-container-core-columns-is-layout-147ade55 wp-block-columns-is-layout-flex\" style=\"padding-top:0px;padding-bottom:0px\">\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:20px;padding-right:20px;padding-bottom:20px;padding-left:20px\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><a href=\"https:\/\/sfb1436.de\/wp-content\/uploads\/2025\/01\/A05_25-28_abstract.png\"><img fetchpriority=\"high\" decoding=\"async\" width=\"638\" height=\"484\" src=\"https:\/\/sfb1436.de\/wp-content\/uploads\/2025\/01\/A05_25-28_abstract.png\" alt=\"A05 25-28 abstract\" class=\"wp-image-25123\" style=\"aspect-ratio:1.6871794871794872;width:453px;height:auto\"\/><\/a><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-left wp-block-paragraph\">Wir untersuchen, wie die extrazellul\u00e4re Matrix (ECM) des Gehirns zu kognitiver Flexibilit\u00e4t (CFL) und Ged\u00e4chtnis bei M\u00e4usen und Menschen beitr\u00e4gt. Mit molekularen Tools werden wir die ECM modifizieren und CFL, Enkodierungs- sowie Ged\u00e4chtnisprozesse bei M\u00e4usen untersuchen und beim Menschen analoge Ma\u00dfe mit peripheren ECM-Markern korrelieren. Diffusions- und quantitative Suszeptibilit\u00e4ts-Bildgebung wollen wir als MRT-basierte Ma\u00dfe f\u00fcr die Hirn-ECM-Integrit\u00e4t bei M\u00e4usen und Menschen testen, um den Zusammenhang zwischen CFL, ECM und Informationsverarbeitung in relevanten Hirnregionen zu erforschen.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns are-vertically-aligned-top is-layout-flex wp-container-core-columns-is-layout-43c3a9c5 wp-block-columns-is-layout-flex\" id=\"project-anchor\" style=\"padding-top:0px;padding-bottom:30px\">\n<div class=\"wp-block-column is-vertically-aligned-top is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-f56f613f wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" id=\"projekt\">\n<div class=\"wp-block-buttons is-horizontal is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-b0be8b0e wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button has-custom-width wp-block-button__width-100 is-style-fill\"><a class=\"wp-block-button__link has-white-color has-project-c-background-color has-text-color has-background has-normal-font-size has-custom-font-size wp-element-button\" href=\"#projekt-a05\"><strong>Unsere Forschung<\/strong><\/a><\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-buttons is-horizontal is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-b0be8b0e wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button has-custom-width wp-block-button__width-100 is-style-fill\"><a class=\"wp-block-button__link has-white-color has-secondary-background-color has-text-color has-background has-normal-font-size has-custom-font-size wp-element-button\" href=\"#ziele\"><strong>Ziele unseres Projektes<\/strong><\/a><\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-buttons is-horizontal is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-b0be8b0e wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button has-custom-width wp-block-button__width-100 is-style-fill\"><a class=\"wp-block-button__link has-white-color has-project-c-background-color has-text-color has-background has-normal-font-size has-custom-font-size wp-element-button\" href=\"#zukunft\"><strong>Blick in die Zukunft<\/strong><\/a><\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-buttons is-horizontal is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-b0be8b0e wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button has-custom-width wp-block-button__width-100 is-style-fill\"><a class=\"wp-block-button__link has-white-color has-secondary-background-color has-text-color has-background has-normal-font-size has-custom-font-size wp-element-button\" href=\"#publications\"><strong>Publikationen<\/strong><\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns alignfull has-tertiary-background-color has-background is-layout-flex wp-container-core-columns-is-layout-763026b3 wp-block-columns-is-layout-flex\" style=\"margin-top:0px;margin-bottom:0px\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" id=\"pi\">\n<h2 class=\"wp-block-heading has-text-align-center\" id=\"gruppenleitung\" style=\"font-style:normal;font-weight:500\">Gruppenleitung<\/h2>\n\n\n<div id=\"awsm-team-25125\" class=\"awsm-grid-wrapper\">\n\t\t\n\t\t<div class=''>\n\t\t<div class=\"gridder awsm-grid drawer-style style-1 grid-2-col \">\n\t\t\t\t\t\t<div id=\"awsm-member-25125-3628\" class=\"awsm-grid-list awsm-grid-card awsm-team-item awsm-scale-anm awsm-all awsm-126\" data-griddercontent=\"#awsm-grid-content-3628\">\n\t\t\t\t\t<span class=\"awsm-team-link-control awsm-grid-list-item awsm-grid-list-item-3628\" data-info=\"3628\">\n\t\t\t\t\t\t<figure>\n\t\t\t\t\t\t<img decoding=\"async\" width=\"789\" height=\"774\" src=\"https:\/\/sfb1436.de\/wp-content\/uploads\/2022\/02\/20210211-Dityatev001__webt.jpg\" class=\"attachment-awsm_team size-awsm_team wp-post-image\" alt=\"SFB 1436 Mitglied Alexander Dityatev\" \/>\t\t\t\t\t\t\t<figcaption>\n\t\t\t\t\t\t\t\t<div class=\"awsm-personal-info\"><span><\/span><h3>Prof. Dr. Alexander Dityatev<\/h3><\/div>\t\t\t\t\t\t\t<\/figcaption>\n\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div id=\"awsm-member-25125-3733\" class=\"awsm-grid-list awsm-grid-card awsm-team-item awsm-scale-anm awsm-all\" data-griddercontent=\"#awsm-grid-content-3733\">\n\t\t\t\t\t<span class=\"awsm-team-link-control awsm-grid-list-item awsm-grid-list-item-3733\" data-info=\"3733\">\n\t\t\t\t\t\t<figure>\n\t\t\t\t\t\t<img decoding=\"async\" width=\"432\" height=\"406\" src=\"https:\/\/sfb1436.de\/wp-content\/uploads\/2022\/02\/Bjoern-Schott_bearbeitet.jpg\" class=\"attachment-awsm_team size-awsm_team wp-post-image\" alt=\"SFB 1436 Mitglied Bj\u00f6rn Schott\" \/>\t\t\t\t\t\t\t<figcaption>\n\t\t\t\t\t\t\t\t<div class=\"awsm-personal-info\"><span><\/span><h3>Dr. Dr. med. Bj\u00f6rn Hendrik Schott<\/h3><\/div>\t\t\t\t\t\t\t<\/figcaption>\n\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div id=\"awsm-member-25125-4161\" class=\"awsm-grid-list awsm-grid-card awsm-team-item awsm-scale-anm awsm-all awsm-126\" data-griddercontent=\"#awsm-grid-content-4161\">\n\t\t\t\t\t<span class=\"awsm-team-link-control awsm-grid-list-item awsm-grid-list-item-4161\" data-info=\"4161\">\n\t\t\t\t\t\t<figure>\n\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"1000\" src=\"https:\/\/sfb1436.de\/wp-content\/uploads\/2022\/02\/20210208-Seidenbecher-001-800x1000.jpg\" class=\"attachment-awsm_team size-awsm_team wp-post-image\" alt=\"SFB 1436 Mitglied Constanze Seidenbecher\" \/>\t\t\t\t\t\t\t<figcaption>\n\t\t\t\t\t\t\t\t<div class=\"awsm-personal-info\"><span><\/span><h3>Prof. Dr. Constanze Seidenbecher<\/h3><\/div>\t\t\t\t\t\t\t<\/figcaption>\n\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<div class=\"awsm-grid-expander style-1\">\n\t\t\t\t\t\t<div id=\"awsm-member-info-25125-3628\"  class=\"awsm-grid-expander style-1\">\n\t\t\t\t<div class=\"awsm-detailed-info\" id=\"awsm-grid-content-3628\">\n\t\t\t\t\t<div class=\"awsm-details\">\n\t\t\t\t\t\t<div class=\"awsm-personal-details\">\n\t\t\t\t\t\t\t<div class=\"awsm-content-scrollbar\">\n\t\t\t\t\t\t\t\t<span><\/span><h2>Prof. Dr. Alexander Dityatev<\/h2>\n<p class=\"wp-block-paragraph\">Alexander Dityatev ist Leiter der Arbeitsgruppe Molekulare Neuroplastizit\u00e4t am DZNE Magdeburg. Er leitet ein Forschungsprogramm zur Rolle der neuronalen extrazellul\u00e4ren Matrix bei neurologischen und neuropsychiatrischen Erkrankungen wie Epilepsie, Alzheimer-Krankheit, vaskul\u00e4re Demenz, Depression und Schizophrenie. Seine Hauptschwerpunkte sind die Biologie der extrazellul\u00e4ren Matrix, synaptische Plastizit\u00e4t und Synaptogenese, Elektrophysiologie, Verhaltensanalyse und Zwei-Photonen-Bildgebung bei wachen M\u00e4usen. Er fungiert als Chefeditor der Sektion \u201eCellular Microenvironment\u201c des Journals <em>Cells<\/em>.<\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"awsm-personal-contact-info\">\n\t\t\t\t\t   <div class=\"awsm-contact-details\"><p><span>Institut:<\/span><a href=\"https:\/\/www.dzne.de\/\" target=\"_blank\">Deutsches Zentrum f\u00fcr Neurodegenerative Erkrankungen (DZNE), Magdeburg<\/a><\/p><p><span>Project Title:<\/span><a href=\"https:\/\/sfb1436.de\/de\/projekte\/integritaet-der-extrazellulaermatrix-als-neurale-ressource-fuer-gedaechtnis-praezision-und-kognitive-flexibilitaet\/\" target=\"_blank\"><b>A05<\/b> Integrit\u00e4t der Extrazellul\u00e4ren Matrix als neuronale Ressource kognitiver Flexibilit\u00e4t<\/a><\/p><\/div><div class=\"awsm-social-icons\"><span><a href=\"mailto:alexander.dityatev@dzne.de\"><i class=\"awsm-icon-mail\" aria-hidden=\"true\"><\/i><\/a><\/span><span><a href=\"tel:+49-391-67-24525\" target=\"_blank\"><i class=\"awsm-icon-phone\" aria-hidden=\"true\"><\/i><\/a><\/span><span><a href=\"https:\/\/www.dzne.de\/forschung\/forschungsbereiche\/grundlagenforschung\/forschungsgruppen\/dityatev\/forschungsschwerpunkte\/\" target=\"_blank\"><i class=\"awsm-icon-link\" aria-hidden=\"true\"><\/i><\/a><\/span><span><a href=\"https:\/\/twitter.com\/dityatevl?lang=ru\" target=\"_blank\"><i class=\"awsm-icon-twitter\" aria-hidden=\"true\"><\/i><\/a><\/span><\/div>\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<div id=\"awsm-member-info-25125-3733\"  class=\"awsm-grid-expander style-1\">\n\t\t\t\t<div class=\"awsm-detailed-info\" id=\"awsm-grid-content-3733\">\n\t\t\t\t\t<div class=\"awsm-details\">\n\t\t\t\t\t\t<div class=\"awsm-personal-details\">\n\t\t\t\t\t\t\t<div class=\"awsm-content-scrollbar\">\n\t\t\t\t\t\t\t\t<span><\/span><h2>Dr. Dr. med. Bj\u00f6rn Hendrik Schott<\/h2>\n<p class=\"wp-block-paragraph\">Bj\u00f6rn Schott ist Facharzt f\u00fcr Psychiatrie und Psychotherapie an der Universit\u00e4t G\u00f6ttingen und gemeinsam mit Constanze Seidenbecher Leiter der Gruppe Synapse-Brain-Cognition in der Abteilung Verhaltensneurologie am LIN Magdeburg. Er befasst sich in seinen Forschungsarbeiten mit der Frage, inwieweit sich genetische und immunologische Faktoren auf Lern- und Ged\u00e4chtnisprozesse des Menschen sowie auf deren St\u00f6rung im Alter und bei neurologischen und psychiatrischen Erkrankungen auswirken. Er fungiert als Associate Editor f\u00fcr <em>Frontiers in Human Neuroscience<\/em>.<\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"awsm-personal-contact-info\">\n\t\t\t\t\t   <div class=\"awsm-contact-details\"><p><span>Institut:<\/span><a href=\"https:\/\/www.uni-goettingen.de\/\" target=\"_blank\">Georg-August-Universit\u00e4t G\u00f6ttingen<\/a><\/p><p><span>:<\/span><a href=\"https:\/\/www.lin-magdeburg.de\/\" target=\"_blank\">Leibniz-Institut f\u00fcr Neurobiologie (LIN) Magdeburg<\/a><\/p><p><span>Project Title:<\/span><a href=\"https:\/\/sfb1436.de\/de\/projekte\/integritaet-der-extrazellulaermatrix-als-neurale-ressource-fuer-gedaechtnis-praezision-und-kognitive-flexibilitaet\/\" target=\"_blank\"><b>A05<\/b> Integrit\u00e4t der Extrazellul\u00e4ren Matrix als neuronale Ressource kognitiver Flexibilit\u00e4t<\/a><\/p><\/div><div class=\"awsm-social-icons\"><span><a href=\"mailto:bjoernhendrik.schott@med.uni-goettingen.de\"><i class=\"awsm-icon-mail\" aria-hidden=\"true\"><\/i><\/a><\/span><span><a href=\"tel:+49-551-3962512\" target=\"_blank\"><i class=\"awsm-icon-phone\" aria-hidden=\"true\"><\/i><\/a><\/span><span><a href=\"https:\/\/psychiatrie.umg.eu\/patienten-besucher\/ambulanzen\/konsiliardienst-fuer-dementielle-erkrankungen\/\" target=\"_blank\"><i class=\"awsm-icon-link\" aria-hidden=\"true\"><\/i><\/a><\/span><span><a href=\"https:\/\/www.lin-magdeburg.de\/forschung\/abteilung-verhaltensneurologie\/ag-synapse-brain-cognition\" target=\"_blank\"><i class=\"awsm-icon-link\" aria-hidden=\"true\"><\/i><\/a><\/span><span><a href=\"https:\/\/twitter.com\/SchottBjorn\" target=\"_blank\"><i class=\"awsm-icon-twitter\" aria-hidden=\"true\"><\/i><\/a><\/span><\/div>\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<div id=\"awsm-member-info-25125-4161\"  class=\"awsm-grid-expander style-1\">\n\t\t\t\t<div class=\"awsm-detailed-info\" id=\"awsm-grid-content-4161\">\n\t\t\t\t\t<div class=\"awsm-details\">\n\t\t\t\t\t\t<div class=\"awsm-personal-details\">\n\t\t\t\t\t\t\t<div class=\"awsm-content-scrollbar\">\n\t\t\t\t\t\t\t\t<span><\/span><h2>Prof. Dr. Constanze Seidenbecher<\/h2>\n<p class=\"wp-block-paragraph\">Constanze Seidenbecher ist molekulare Neurowissenschaftlerin und Mitglied des SFB1436-Lenkungsausschusses. Sie ist Leiterin des Synapse-Brain-Cogniton-Labors am Leibniz-Institut f\u00fcr Neurobilogoie (LIN) in Magdeburg und Professorin an der Otto-von-Guericke-Universit\u00e4t. Sie erwarb einen Abschluss in Biochemie an der Martin-Luther-Universit\u00e4t Halle und promovierte in Molekularen Neurowissenschaften. Ihr wissenschaftlicher Schwerpunkt gilt den neuronalen ECM-vermittelten Mechanismen, die der neuronalen Plastizit\u00e4t, der Kognition und dem Ged\u00e4chtnis bei M\u00e4usen und Menschen zugrunde liegen. Sie arbeitet im SynGO-Konsortium mit, ist Senior Editor des Journal of Neurochemistry und Vorstandsmitglied der International Society for Neurochemistry. Von 2004 bis 2020 war Constanze Seidenbecher zudem Leiterin f\u00fcr Wissenschaftsmanagement und \u00d6ffentlichkeitsarbeit am LIN, und seit 2007 ist sie Mitglied im Lenkungsausschuss mehrerer lokaler und nationaler Forschungsverb\u00fcnde wie dem Deutschen Zentrum f\u00fcr Seelische Gesundheit Magdeburg &#8211; Jena &#8211; Halle und dem Center for Behavioral Brain Sciences (CBBS) Magdeburg.<\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"awsm-personal-contact-info\">\n\t\t\t\t\t   <div class=\"awsm-contact-details\"><p><span>Institut:<\/span><a href=\"https:\/\/www.lin-magdeburg.de\/\" target=\"_blank\">Leibniz-Institut\u00a0f\u00fcr Neurobiologie (LIN)\u00a0Magdeburg<\/a><\/p><p><span>Project Title:<\/span><a href=\"https:\/\/sfb1436.de\/de\/projekte\/integritaet-der-extrazellulaermatrix-als-neurale-ressource-fuer-gedaechtnis-praezision-und-kognitive-flexibilitaet\/\" target=\"_blank\"><b>A05<\/b> Integrit\u00e4t der Extrazellul\u00e4ren Matrix als neuronale Ressource kognitiver Flexibilit\u00e4t<\/a><\/p><\/div><div class=\"awsm-social-icons\"><span><a href=\"mailto:seidenc@lin-magdeburg.de\"><i class=\"awsm-icon-mail\" aria-hidden=\"true\"><\/i><\/a><\/span><span><a href=\"tel:+49-391-6263-92401\" target=\"_blank\"><i class=\"awsm-icon-phone\" aria-hidden=\"true\"><\/i><\/a><\/span><span><a href=\"https:\/\/www.lin-magdeburg.de\/forschung\/abteilung-verhaltensneurologie\/ag-synapse-brain-cognition\" target=\"_blank\"><i class=\"awsm-icon-link\" aria-hidden=\"true\"><\/i><\/a><\/span><\/div>\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t<\/div>\n\t<\/div>\n\n\n\n\n<div class=\"wp-block-columns justify-content-center is-layout-flex wp-container-core-columns-is-layout-f56f613f wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:1350px\">\n<h2 class=\"wp-block-heading has-text-align-center\" id=\"gruppenmitglieder\" style=\"font-style:normal;font-weight:500\">Gruppenmitglieder<\/h2>\n\n\n<div id=\"awsm-team-25126\" class=\"awsm-grid-wrapper\">\n\t\t\n\t\t<div class=''>\n\t\t<div class=\"gridder awsm-grid drawer-style style-1 grid-2-col \">\n\t\t\t\t\t\t<div id=\"awsm-member-25126-3595\" class=\"awsm-grid-list awsm-grid-card awsm-team-item awsm-scale-anm awsm-all\" data-griddercontent=\"#awsm-grid-content-3595\">\n\t\t\t\t\t<span class=\"awsm-team-link-control awsm-grid-list-item awsm-grid-list-item-3595\" data-info=\"3595\">\n\t\t\t\t\t\t<figure>\n\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"1000\" src=\"https:\/\/sfb1436.de\/wp-content\/uploads\/2022\/05\/20210526-184-Stephan-Aleshin-800x1000.jpg\" class=\"attachment-awsm_team size-awsm_team wp-post-image\" alt=\"SFB 1436 Mitglied Stepan Aleshin\" \/>\t\t\t\t\t\t\t<figcaption>\n\t\t\t\t\t\t\t\t<div class=\"awsm-personal-info\"><span><\/span><h3>Dr. Stepan Aleshin<\/h3><\/div>\t\t\t\t\t\t\t<\/figcaption>\n\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div id=\"awsm-member-25126-28093\" class=\"awsm-grid-list awsm-grid-card awsm-team-item awsm-scale-anm awsm-all\" data-griddercontent=\"#awsm-grid-content-28093\">\n\t\t\t\t\t<span class=\"awsm-team-link-control awsm-grid-list-item awsm-grid-list-item-28093\" data-info=\"28093\">\n\t\t\t\t\t\t<figure>\n\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"1000\" src=\"https:\/\/sfb1436.de\/wp-content\/uploads\/2025\/06\/Carla-Cangalaya-Lira-800x1000.jpg\" class=\"attachment-awsm_team size-awsm_team wp-post-image\" alt=\"SFB 1436 Mitglied Carla Cangalaya Lira\" \/>\t\t\t\t\t\t\t<figcaption>\n\t\t\t\t\t\t\t\t<div class=\"awsm-personal-info\"><span><\/span><h3>Dr. Carla Cangalaya Lira<\/h3><\/div>\t\t\t\t\t\t\t<\/figcaption>\n\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div id=\"awsm-member-25126-3620\" class=\"awsm-grid-list awsm-grid-card awsm-team-item awsm-scale-anm awsm-all\" data-griddercontent=\"#awsm-grid-content-3620\">\n\t\t\t\t\t<span class=\"awsm-team-link-control awsm-grid-list-item awsm-grid-list-item-3620\" data-info=\"3620\">\n\t\t\t\t\t\t<figure>\n\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"667\" src=\"https:\/\/sfb1436.de\/wp-content\/uploads\/2022\/05\/20210615-585-MargaritaDarna-800x667.jpg\" class=\"attachment-awsm_team size-awsm_team wp-post-image\" alt=\"Margarita Darna\" \/>\t\t\t\t\t\t\t<figcaption>\n\t\t\t\t\t\t\t\t<div class=\"awsm-personal-info\"><span><\/span><h3>Margarita Darna<\/h3><\/div>\t\t\t\t\t\t\t<\/figcaption>\n\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div id=\"awsm-member-25126-29425\" class=\"awsm-grid-list awsm-grid-card awsm-team-item awsm-scale-anm awsm-all\" data-griddercontent=\"#awsm-grid-content-29425\">\n\t\t\t\t\t<span class=\"awsm-team-link-control awsm-grid-list-item awsm-grid-list-item-29425\" data-info=\"29425\">\n\t\t\t\t\t\t<figure>\n\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"1000\" src=\"https:\/\/sfb1436.de\/wp-content\/uploads\/2025\/11\/Manoj_Pandiri-800x1000.webp\" class=\"attachment-awsm_team size-awsm_team wp-post-image\" alt=\"CRC 1436 member Manoj Pandiri\" \/>\t\t\t\t\t\t\t<figcaption>\n\t\t\t\t\t\t\t\t<div class=\"awsm-personal-info\"><span><\/span><h3>Manoj Pandiri<\/h3><\/div>\t\t\t\t\t\t\t<\/figcaption>\n\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div id=\"awsm-member-25126-3724\" class=\"awsm-grid-list awsm-grid-card awsm-team-item awsm-scale-anm awsm-all\" data-griddercontent=\"#awsm-grid-content-3724\">\n\t\t\t\t\t<span class=\"awsm-team-link-control awsm-grid-list-item awsm-grid-list-item-3724\" data-info=\"3724\">\n\t\t\t\t\t\t<figure>\n\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"1000\" src=\"https:\/\/sfb1436.de\/wp-content\/uploads\/2022\/02\/Anni-Richter-800x1000.webp\" class=\"attachment-awsm_team size-awsm_team wp-post-image\" alt=\"CRC 1436 member Dr. Anni Richter\" \/>\t\t\t\t\t\t\t<figcaption>\n\t\t\t\t\t\t\t\t<div class=\"awsm-personal-info\"><span><\/span><h3>Dr. Anni Richter<\/h3><\/div>\t\t\t\t\t\t\t<\/figcaption>\n\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<div class=\"awsm-grid-expander style-1\">\n\t\t\t\t\t\t<div id=\"awsm-member-info-25126-3595\"  class=\"awsm-grid-expander style-1\">\n\t\t\t\t<div class=\"awsm-detailed-info\" id=\"awsm-grid-content-3595\">\n\t\t\t\t\t<div class=\"awsm-details\">\n\t\t\t\t\t\t<div class=\"awsm-personal-details\">\n\t\t\t\t\t\t\t<div class=\"awsm-content-scrollbar\">\n\t\t\t\t\t\t\t\t<span><\/span><h2>Dr. Stepan Aleshin<\/h2>\n<p class=\"wp-block-paragraph\">Ich arbeite als Postdoc in der Gruppe f\u00fcr molekulare Neuroplastizit\u00e4t am DZNE in Magdeburg. Ich habe einen Abschluss in Virologie (MSc) und Molekularbiologie (PhD). W\u00e4hrend meiner wissenschaftlichen Laufbahn interessierte ich mich f\u00fcr Verhaltensexperimente und deren Modellierung, neurodegenerative Krankheiten und integrative\/theoretische Neurowissenschaften. Neben meiner wissenschaftlichen Arbeit\u00a0reise ich gerne und f\u00fchre Orientierungsl\u00e4ufe durch.<\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"awsm-personal-contact-info\">\n\t\t\t\t\t   <div class=\"awsm-contact-details\"><p><span>Institut:<\/span><a href=\"https:\/\/www.dzne.de\/\" target=\"_blank\">Deutsches Zentrum f\u00fcr Neurodegenerative Erkrankungen (DZNE), Magdeburg<\/a><\/p><p><span>Projekt:<\/span><a href=\"https:\/\/sfb1436.de\/de\/projekte\/integritaet-der-extrazellulaermatrix-als-neurale-ressource-fuer-gedaechtnis-praezision-und-kognitive-flexibilitaet\/\" target=\"_blank\"><b>A05<\/b> Integrit\u00e4t der Extrazellul\u00e4ren Matrix als neuronale Ressource kognitiver Flexibilit\u00e4t<\/a><\/p><\/div><div class=\"awsm-social-icons\"><span><a href=\"mailto:Stepan.Aleshin@dzne.de\"><i class=\"awsm-icon-mail\" aria-hidden=\"true\"><\/i><\/a><\/span><span><a href=\"https:\/\/www.dzne.de\/forschung\/forschungsbereiche\/grundlagenforschung\/forschungsgruppen\/dityatev\/forschungsschwerpunkte\/\" target=\"_blank\"><i class=\"awsm-icon-link\" aria-hidden=\"true\"><\/i><\/a><\/span><\/div>\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<div id=\"awsm-member-info-25126-28093\"  class=\"awsm-grid-expander style-1\">\n\t\t\t\t<div class=\"awsm-detailed-info\" id=\"awsm-grid-content-28093\">\n\t\t\t\t\t<div class=\"awsm-details\">\n\t\t\t\t\t\t<div class=\"awsm-personal-details\">\n\t\t\t\t\t\t\t<div class=\"awsm-content-scrollbar\">\n\t\t\t\t\t\t\t\t<span><\/span><h2>Dr. Carla Cangalaya Lira<\/h2>\n<p class=\"wp-block-paragraph\">coming soon<\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"awsm-personal-contact-info\">\n\t\t\t\t\t   <div class=\"awsm-contact-details\"><p><span>Institut:<\/span><a href=\"https:\/\/www.dzne.de\/\" target=\"_blank\">Deutsches Zentrum f\u00fcr Neurodegenerative Erkrankungen (DZNE), Magdeburg<\/a><\/p><p><span>Projekt:<\/span><a href=\"https:\/\/sfb1436.de\/de\/projekte\/integritaet-der-extrazellulaermatrix-als-neurale-ressource-fuer-gedaechtnis-praezision-und-kognitive-flexibilitaet\/\" target=\"_blank\"><b>A05<\/b> Integrit\u00e4t der Extrazellul\u00e4ren Matrix als neuronale Ressource kognitiver Flexibilit\u00e4t<\/a><\/p><\/div><div class=\"awsm-social-icons\"><span><a href=\"mailto:Carla-Marcia.Cangalaya-Lira@dzne.de\"><i class=\"awsm-icon-mail\" aria-hidden=\"true\"><\/i><\/a><\/span><span><a href=\"https:\/\/www.dzne.de\/forschung\/forschungsbereiche\/grundlagenforschung\/forschungsgruppen\/dityatev\/forschungsschwerpunkte\/\" target=\"_blank\"><i class=\"awsm-icon-link\" aria-hidden=\"true\"><\/i><\/a><\/span><\/div>\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<div id=\"awsm-member-info-25126-3620\"  class=\"awsm-grid-expander style-1\">\n\t\t\t\t<div class=\"awsm-detailed-info\" id=\"awsm-grid-content-3620\">\n\t\t\t\t\t<div class=\"awsm-details\">\n\t\t\t\t\t\t<div class=\"awsm-personal-details\">\n\t\t\t\t\t\t\t<div class=\"awsm-content-scrollbar\">\n\t\t\t\t\t\t\t\t<span><\/span><h2>Margarita Darna<\/h2>\n<p class=\"wp-block-paragraph\">Margarita ist Doktorandin am Leibniz-Institut f\u00fcr Neurobiologie. Sie studierte Neurobiologie und interessiert sich f\u00fcr menschliche Kognition. In ihrer Forschung verwendet sie nicht-invasive Methoden wie Elektroenzephalographie und Magnetresonanztomographie, um das menschliche Verhalten zu untersuchen. Durch Computer-basierte Methodenversucht sie herauszufinden, welche Faktoren bei der Kognition eine Rolle spielen k\u00f6nnten.<\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"awsm-personal-contact-info\">\n\t\t\t\t\t   <div class=\"awsm-contact-details\"><p><span>Institut:<\/span><a href=\"https:\/\/www.lin-magdeburg.de\/\" target=\"_blank\">Leibniz-Institut\u00a0f\u00fcr Neurobiologie (LIN)\u00a0Magdeburg<\/a><\/p><p><span>Projekt:<\/span><a href=\"\/de\/projekte\/integritaet-der-extrazellulaermatrix-als-neurale-ressource-fuer-gedaechtnis-praezision-und-kognitive-flexibilitaet\/\" target=\"_blank\"><b>A05<\/b> Integrit\u00e4t der Extrazellul\u00e4ren Matrix als neuronale Ressource kognitiver Flexibilit\u00e4t<\/a><\/p><\/div><div class=\"awsm-social-icons\"><span><a href=\"mailto:margarita.darna@lin-magdeburg.de\"><i class=\"awsm-icon-mail\" aria-hidden=\"true\"><\/i><\/a><\/span><span><a href=\"https:\/\/www.lin-magdeburg.de\/forschung\/abteilung-verhaltensneurologie\/ag-synapse-brain-cognition\" target=\"_blank\"><i class=\"awsm-icon-link\" aria-hidden=\"true\"><\/i><\/a><\/span><\/div>\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<div id=\"awsm-member-info-25126-29425\"  class=\"awsm-grid-expander style-1\">\n\t\t\t\t<div class=\"awsm-detailed-info\" id=\"awsm-grid-content-29425\">\n\t\t\t\t\t<div class=\"awsm-details\">\n\t\t\t\t\t\t<div class=\"awsm-personal-details\">\n\t\t\t\t\t\t\t<div class=\"awsm-content-scrollbar\">\n\t\t\t\t\t\t\t\t<span><\/span><h2>Manoj Pandiri<\/h2>\n<p class=\"wp-block-paragraph\">coming soon<\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"awsm-personal-contact-info\">\n\t\t\t\t\t   <div class=\"awsm-contact-details\"><p><span>:<\/span><a href=\"https:\/\/www.lin-magdeburg.de\/\" target=\"_blank\">Leibniz-Institut\u00a0f\u00fcr Neurobiologie (LIN)\u00a0Magdeburg<\/a><\/p><p><span>:<\/span><a href=\"\/de\/projekte\/integritaet-der-extrazellulaermatrix-als-neurale-ressource-fuer-gedaechtnis-praezision-und-kognitive-flexibilitaet\/\" target=\"_blank\"><b>A05<\/b> Integrit\u00e4t der Extrazellul\u00e4ren Matrix als neuronale Ressource kognitiver Flexibilit\u00e4t<\/a><\/p><\/div><div class=\"awsm-social-icons\"><span><a href=\"mailto:Manoj.Pandiri@lin-magdeburg.de\"><i class=\"awsm-icon-mail\" aria-hidden=\"true\"><\/i><\/a><\/span><span><a href=\"https:\/\/www.lin-magdeburg.de\/forschung\/abteilung-verhaltensneurologie\/ag-synapse-brain-cognition\" target=\"_blank\"><i class=\"awsm-icon-link\" aria-hidden=\"true\"><\/i><\/a><\/span><\/div>\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<div id=\"awsm-member-info-25126-3724\"  class=\"awsm-grid-expander style-1\">\n\t\t\t\t<div class=\"awsm-detailed-info\" id=\"awsm-grid-content-3724\">\n\t\t\t\t\t<div class=\"awsm-details\">\n\t\t\t\t\t\t<div class=\"awsm-personal-details\">\n\t\t\t\t\t\t\t<div class=\"awsm-content-scrollbar\">\n\t\t\t\t\t\t\t\t<span><\/span><h2>Dr. Anni Richter<\/h2>\n<p class=\"wp-block-paragraph\">Anni ist Postdoc-Wissenschaftlerin am Leibniz-Institut f\u00fcr Neurobiologie. Sie hat einen Hintergrund in Psychologie und ist an menschlicher Kognition interessiert. In ihrer Forschung konzentriert sie sich auf die dopaminerge Modulation des impliziten und expliziten Lernens, die Synaptogenetik des menschlichen Lernens und Ged\u00e4chtnisses und multimodale Marker des neurokognitiven Alterns unter Verwendung nicht-invasiver Methoden wie der Kernspintomographie.<\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"awsm-personal-contact-info\">\n\t\t\t\t\t   <div class=\"awsm-contact-details\"><p><span>Institut:<\/span><a href=\"https:\/\/www.lin-magdeburg.de\/\" target=\"_blank\">Leibniz-Institut f\u00fcr Neurobiologie (LIN) Magdeburg<\/a><\/p><p><span>Projekt:<\/span><a href=\"\/de\/projekte\/integritaet-der-extrazellulaermatrix-als-neurale-ressource-fuer-gedaechtnis-praezision-und-kognitive-flexibilitaet\/\" target=\"_blank\"><b>A05<\/b> Integrit\u00e4t der Extrazellul\u00e4ren Matrix als neuronale Ressource kognitiver Flexibilit\u00e4t<\/a><\/p><\/div><div class=\"awsm-social-icons\"><span><a href=\"mailto:anni.richter@lin-magdeburg.de\"><i class=\"awsm-icon-mail\" aria-hidden=\"true\"><\/i><\/a><\/span><span><a href=\"https:\/\/www.lin-magdeburg.de\/forschung\/abteilung-verhaltensneurologie\/ag-synapse-brain-cognition\" target=\"_blank\"><i class=\"awsm-icon-link\" aria-hidden=\"true\"><\/i><\/a><\/span><\/div>\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t<\/div>\n\t<\/div>\n\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns alignwide justify-content-center is-layout-flex wp-container-core-columns-is-layout-f56f613f wp-block-columns-is-layout-flex\" id=\"projekt-a05\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-columns justify-content-center is-layout-flex wp-container-core-columns-is-layout-f56f613f wp-block-columns-is-layout-flex\" id=\"projekt\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:0px;padding-right:50px;padding-bottom:0px;padding-left:50px;flex-basis:1350px\">\n<h2 class=\"wp-block-heading has-text-align-center has-project-c-color has-text-color\" id=\"was-ist-die-extrazellulare-matrix\"><strong>Was ist die Extrazellul\u00e4re Matrix?<\/strong><\/h2>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\">Die Extrazellul\u00e4re Matrix (ECM) im Gehirn besteht aus einem dreidimensionalen Geflecht von Makromolek\u00fclen wie Proteoglycanen, Glycoproteinen und Hyalurons\u00e4ure. Diese Molek\u00fcle werden von den Neuronen und den Gliazellen produziert und in den Extrazellul\u00e4rraum abgegeben, wo sie Gel-artige Makrostrukturen bilden. Besonders um die hemmend wirkenden Parvalbumin-positiven Zellen herum findet man sogenannte Perineuronale Netze als Spezialisierung der ECM, die die Synapsen umgeben und isolieren.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns are-vertically-aligned-top is-layout-flex wp-container-core-columns-is-layout-f56f613f wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-top is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<h3 class=\"wp-block-heading has-white-color has-secondary-background-color has-text-color has-background\" id=\"besteht-ein-zusammenhang-zwischen-der-hirnaktivitat-und-der-ecm-zusammensetzung\">Besteht ein Zusammenhang zwischen der Hirnaktivit\u00e4t und <br>der ECM-Zusammensetzung?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\" id=\"besteht-ein-zusammenhang-zwischen-der-hirnaktivitat-und-der-ecm-zusammensetzung\">Die molekulare Zusammensetzung der neuralen ECM \u00e4ndert sich w\u00e4hrend der Reifung und Alterung des Hirns sowie bei Erkrankungen wie Tumoren, Hirntrauma, Epilepsie, Depression, Schizophrenie oder neurodegenerativen Krankheiten (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32594588\/\" target=\"_blank\" rel=\"noreferrer noopener\">Ulbrich et al., 2021<\/a>). Auch in Abh\u00e4ngigkeit vom Aktivit\u00e4tszustand gesunder neuronaler Netzwerke wird die ECM moduliert. Beispielsweise f\u00fchrt die Aktivierung von Dopamin-Rezeptoren in Neuronen der Hirnrinde dazu, dass ECM-Proteoglycane vermehrt durch extrazellul\u00e4re Proteasen gespalten werden (<a href=\"https:\/\/www.mdpi.com\/2073-4409\/9\/2\/260\" target=\"_blank\" rel=\"noreferrer noopener\">Mitl\u00f6hner et al., 2020<\/a>). Wird die Hirn-Matrix experimentell abgebaut, dann \u00e4ndern sich die plastischen Eigenschaften des Gehirns. Beispielsweise steigt die kognitive Flexibilit\u00e4t von W\u00fcstenrennm\u00e4usen in einer akustischen Umlern-Aufgabe, wenn die ECM in der H\u00f6rrinde vor dem Umlernen abgebaut wird (<a href=\"https:\/\/www.pnas.org\/content\/111\/7\/2800\" target=\"_blank\" rel=\"noreferrer noopener\">Happel et al., 2014<\/a>) und die Verringerung der Neurocan-Menge erh\u00f6ht die spontane neuronale Aktivit\u00e4t <br>(<a href=\"https:\/\/doi.org\/10.1016\/j.matbio.2025.01.001\" target=\"_blank\" rel=\"noreferrer noopener\">Baidoe-Ansah et al., 2025<\/a>).<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-top is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<h3 class=\"wp-block-heading has-white-color has-secondary-background-color has-text-color has-background\" id=\"matrix-variabilitat-und-kognitive-flexibigenetische-variabilitat-in-ecm-kodierenden-genen\">Genetische Variabilit\u00e4t in <br>ECM-kodierenden Genen<br><br><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Im gesamten Genom findet sich eine Vielzahl von Einzelnucleotid-Polymorphismen, die unsere genetische Variabilit\u00e4t ausmachen, der auch die ECM-kodierenden Gene unterliegen. Im NCAN-Gen, welches das Proteoglycan Neurocan kodiert, gibt es einen Polymorphismus, der als genomweiter Risikofaktor f\u00fcr das Auftreten von neuropsychiatrischen Erkrankungen wie Schizophrenie und bipolarer St\u00f6rung gilt. Wir konnten zeigen, dass dieser Polymorphismus bei gesunden Erwachsenen mit der Ged\u00e4chtnisleistung und der Aktivierung des Hippocampus in einer Lernaufgabe sowie mit der Dichte der grauen Substanz im pr\u00e4frontalen Cortex korreliert (<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejn.14872\" target=\"_blank\" rel=\"noreferrer noopener\">Assmann et al., 2021<\/a>).<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns alignfull are-vertically-aligned-center has-white-color has-secondary-background-color has-text-color has-background is-layout-flex wp-container-core-columns-is-layout-952ccc31 wp-block-columns-is-layout-flex\" id=\"ziele\" style=\"margin-top:0px;margin-bottom:0px;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:20px;padding-right:20px;padding-bottom:20px;padding-left:20px\">\n<h2 class=\"wp-block-heading has-text-align-right\" id=\"die-ziele-unseres-projektes\" style=\"font-style:normal;font-weight:500\">Die Ziele unseres Projektes<\/h2>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center has-white-color has-project-c-background-color has-text-color has-background is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:50px;padding-right:150px;padding-bottom:50px;padding-left:150px\">\n<p class=\"has-text-align-left wp-block-paragraph\">Unser Ziel ist es, bei Nagetieren und Menschen die Bedeutung der ECM-Integrit\u00e4t im frontalen Kortex als potenzielle Quelle f\u00fcr kognitive Reserven zur Aufrechterhaltung der kognitiven Flexibilit\u00e4t im Alter oder unter neurodegenerativen Bedingungen zu untersuchen. Wir werden untersuchen, wie die neuronale ECM-Zusammensetzung die kognitive Flexibilit\u00e4t und Ged\u00e4chtnispr\u00e4zision \u00fcber die Modulation inhibitorischer Schaltkreise beeinflusst, und wir werden die Engrammeigenschaften und die neuronale Aktivit\u00e4t bei Nagetieren nach Modulation ihrer ECM-Integrit\u00e4t und PNN-Zusammensetzung messen. Gemeinsam mit Z03, B06 und C01 werden wir ECM-Serumspiegel und Expressionsmuster im Gehirn sowie SNPs in ECM-kodierenden Genen mit kognitiver Flexibilit\u00e4t und Ged\u00e4chtnis sowie mit potenziellen MRT-basierten Ma\u00dfst\u00e4ben f\u00fcr die ECM-Integrit\u00e4t korrelieren.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-f56f613f wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<h3 class=\"wp-block-heading has-white-color has-project-c-background-color has-text-color has-background\" id=\"matrix-defiziente-mause\">Matrix-defiziente M\u00e4use &nbsp;<br><br><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Um die Bedeutung der ECM f\u00fcr diese Prozesse zu analysieren, arbeiten wir mit M\u00e4usen, denen die Gene f\u00fcr die zentralen ECM-Komponenten Brevican und Neurocan fehlen. Au\u00dferdem schalten wir bei normalen M\u00e4usen die beiden Proteoglycane \u00fcber einen Knockdown mittels shRNA spezifisch im pr\u00e4frontalen Cortex aus. Wir werden nun unsere neu entwickelten Instrumente einsetzen, um die ECM-Strukturen in M\u00e4usen zu schw\u00e4chen oder zu st\u00e4rken, um akute von chronischen Auswirkungen dieser Gene auf die neuronale Erregbarkeit und das Verhalten zu unterscheiden und die Bedeutung des pr\u00e4frontalen Kortex f\u00fcr die kognitive Flexibilit\u00e4t weiter zu erhellen.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<h3 class=\"wp-block-heading has-white-color has-project-c-background-color has-text-color has-background\" id=\"matrix-variabilitat-und-kognitiveflexibilitat-beim-menschen\">Genetische Variabilit\u00e4t bei ECM-kodierenden Genen<br><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Im gesamten Genom gibt es zahlreiche polymorphe Stellen, die unsere genetische Variabilit\u00e4t ausmachen, von der auch die ECM-kodierenden Gene betroffen sind. Im NCAN-Gen, das f\u00fcr das Proteoglykan Neurocan kodiert, gibt es einen Polymorphismus, der als genomweiter Risikofaktor f\u00fcr neuropsychiatrische St\u00f6rungen wie Schizophrenie und bipolare St\u00f6rung gilt. Wir haben gezeigt, dass dieser Polymorphismus mit der Ged\u00e4chtnisleistung und den Aktivierungsmustern des Hippocampus bei einer Lernaufgabe sowie mit der Dichte der grauen Substanz im pr\u00e4frontalen Kortex bei gesunden Erwachsenen korreliert (<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejn.14872\" target=\"_blank\" rel=\"noreferrer noopener\">Assmann et al., 2021<\/a>). Dar\u00fcber hinaus haben wir Polymorphismen im BCAN-Gen, das f\u00fcr Brevican kodiert, identifiziert, die mit Messungen der kognitiven Flexibilit\u00e4t beim Menschen korrelieren.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns alignfull has-tertiary-background-color has-background is-layout-flex wp-container-core-columns-is-layout-952ccc31 wp-block-columns-is-layout-flex\" id=\"zukunft\" style=\"margin-top:0px;margin-bottom:0px;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<div class=\"wp-block-cover is-repeated\" style=\"min-height:411px;aspect-ratio:unset;\"><div class=\"wp-block-cover__image-background wp-image-1904 is-repeated\" style=\"background-position:50% 50%;background-image:url(https:\/\/sfb1436.de\/wp-content\/uploads\/2022\/01\/A05_Projektbild.jpg)\"><\/div><span aria-hidden=\"true\" class=\"wp-block-cover__background has-background-dim-20 has-background-dim\"><\/span><div class=\"wp-block-cover__inner-container is-layout-flow wp-block-cover-is-layout-flow\">\n<p class=\"has-text-align-center has-large-font-size wp-block-paragraph\"><\/p>\n<\/div><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center has-tertiary-background-color has-background is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:30px;padding-right:150px;padding-bottom:30px;padding-left:150px\">\n<h2 class=\"wp-block-heading has-text-align-left\" id=\"ein-blick-in-die-zukunft\" style=\"font-style:normal;font-weight:500\">Ein Blick in die Zukunft<\/h2>\n\n\n\n<p class=\"has-text-align-left wp-block-paragraph\">Durch parallele Untersuchungen an M\u00e4usen und Menschen wollen wir die grundlegenden Mechanismen untersuchen, wie die Mikroumgebung der Neuronen im pr\u00e4frontalen Kortex die F\u00e4higkeit zur kognitiven Flexibilit\u00e4t beeinflussen kann. Der Nachweis von ECM-Komponenten des Gehirns im Serum von Patienten k\u00f6nnte Aufschluss \u00fcber die Umbauprozesse der neuronalen ECM bei Krankheiten geben, die mit einer eingeschr\u00e4nkten kognitiven Flexibilit\u00e4t einhergehen, und die Entwicklung pharmakologischer oder viraler Instrumente zur Kontrolle der Matrixintegrit\u00e4t im Gehirn anregen. Die erfolgreiche Etablierung von Proxies f\u00fcr die neuronale ECM-Integrit\u00e4t in MRT-Daten k\u00f6nnte den Weg f\u00fcr eine nicht-invasive In-vivo-\u00dcberwachung des ECM-Umbaus ebnen.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns alignfull is-layout-flex wp-container-core-columns-is-layout-dca53f0c wp-block-columns-is-layout-flex\" id=\"publications\" style=\"margin-top:0px;margin-bottom:0px\">\n<div class=\"wp-block-column has-project-c-background-color has-background is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:100%\">\n<section class=\"wp-block-group alignfull is-layout-flow wp-block-group-is-layout-flow\" style=\"padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<div class=\"wp-block-columns alignfull has-project-c-background-color has-background is-layout-flex wp-container-core-columns-is-layout-44579ee7 wp-block-columns-is-layout-flex\" style=\"margin-top:0px;margin-bottom:0px;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h2 class=\"wp-block-heading has-text-align-center has-white-color has-text-color\" id=\"publikationen-des-projektes-a05\"><strong>Publikationen des Projektes A05<\/strong><\/h2>\n\n\n\n\t\t\t<div class=\"wp-block-uagb-post-carousel uagb-post-grid project-slider uagb-post__image-position-top uagb-post__image-disabled uagb-block-7ed4a94a     uagb-post__arrow-outside uagb-slick-carousel uagb-post__items uagb-post__columns-3 is-carousel uagb-post__columns-tablet-2 uagb-post__columns-mobile-1\" data-total=\"2\" style=\"\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t<article class=\"uagb-post__inner-wrap\">\t\t\t\t\t\t\t\t<h4 class=\"uagb-post__title uagb-post__text\">\n\t\t\t\t<a href=\"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2026.04.001\" target=\"_blank\" rel=\"bookmark noopener noreferrer\">Altered theta distribution and coherence during set-shifting in older age<\/a>\n\t\t\t<\/h4>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t\t<time datetime=\"2026-04-10T12:53:54+02:00\" class=\"uagb-post__date\">\n\t\t\t\t<span class=\"dashicons-calendar dashicons\"><\/span>\t\t\t\t\t10.04.2026\t\t\t\t<\/time>\n\t\t\t\t\t\t\t<div class=\"uagb-post__text\">\n\t\t\t\t\t<span class='uagb-post__taxonomy'>\n\t\t\t\t\t\t<span class=\"dashicons-tag dashicons\"><\/span>\t\t\t\t\t\t<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a05-de\/\">A05<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/b05-de\/\">B05<\/a>\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class='uagb-post__text uagb-post__excerpt'>\n\t\t\t\t\t<p>Margarita Darna, Anni Richter, Jens-Max Hopf, Constanze I. Seidenbecher, Bj\u00f6rn H. Schott <span class=\"excerpt-magazin\">Neurobiology of Aging (2026)<\/span><\/p>\n<\/span>\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<article class=\"uagb-post__inner-wrap\">\t\t\t\t\t\t\t\t<h4 class=\"uagb-post__title uagb-post__text\">\n\t\t\t\t<a href=\"https:\/\/doi.org\/10.1007\/s11357-025-01764-w\" target=\"_blank\" rel=\"bookmark noopener noreferrer\">A physically and mentally active lifestyle relates to younger brain and cognitive age<\/a>\n\t\t\t<\/h4>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t\t<time datetime=\"2025-07-07T13:33:33+02:00\" class=\"uagb-post__date\">\n\t\t\t\t<span class=\"dashicons-calendar dashicons\"><\/span>\t\t\t\t\t07.07.2025\t\t\t\t<\/time>\n\t\t\t\t\t\t\t<div class=\"uagb-post__text\">\n\t\t\t\t\t<span class='uagb-post__taxonomy'>\n\t\t\t\t\t\t<span class=\"dashicons-tag dashicons\"><\/span>\t\t\t\t\t\t<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a05-de\/\">A05<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/b02-de\/\">B02<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/b04-de\/\">B04<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/z03-de\/\">Z03<\/a>\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class='uagb-post__text uagb-post__excerpt'>\n\t\t\t\t\t<p>Niklas Behrenbruch,&nbsp;Svenja Schwarck,&nbsp;Beate Schumann-Werner,&nbsp;E\u00f3in N. Molloy,&nbsp;Berta Garcia-Garcia,&nbsp;Anne Hochkeppler,&nbsp;Larissa Fischer,&nbsp;Anna-Therese B\u00fcchel,&nbsp;Enise I. Incesoy,&nbsp;Jose Bernal,&nbsp;Niklas Vockert,&nbsp;Patrick M\u00fcller,&nbsp;Gusalija Behnisch,&nbsp;B\u00e1rbara Morgado,&nbsp;Hermann Esselmann,&nbsp;Constanze I. Seidenbecher,&nbsp;Bj\u00f6rn H. Schott,&nbsp;Henryk Barthel,&nbsp;Osama Sabri,&nbsp;Jens Wiltfang,&nbsp;Michael C. Kreissl,&nbsp;Emrah D\u00fczel&nbsp;&amp;&nbsp;Anne Maass <span class=\"excerpt-magazin\">GeroScience (2025)<\/span><\/p>\n<\/span>\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<article class=\"uagb-post__inner-wrap\">\t\t\t\t\t\t\t\t<h4 class=\"uagb-post__title uagb-post__text\">\n\t\t\t\t<a href=\"https:\/\/doi.org\/10.1016\/j.nbas.2025.100142\" target=\"_blank\" rel=\"bookmark noopener noreferrer\">Frontal theta oscillations and cognitive flexibility: Age-related modulations in EEG activity<\/a>\n\t\t\t<\/h4>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t\t<time datetime=\"2025-07-01T14:58:19+02:00\" class=\"uagb-post__date\">\n\t\t\t\t<span class=\"dashicons-calendar dashicons\"><\/span>\t\t\t\t\t01.07.2025\t\t\t\t<\/time>\n\t\t\t\t\t\t\t<div class=\"uagb-post__text\">\n\t\t\t\t\t<span class='uagb-post__taxonomy'>\n\t\t\t\t\t\t<span class=\"dashicons-tag dashicons\"><\/span>\t\t\t\t\t\t<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a05-de\/\">A05<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/b05-de\/\">B05<\/a>\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class='uagb-post__text uagb-post__excerpt'>\n\t\t\t\t\t<p>Margarita&nbsp;Darna,&nbsp;Christopher&nbsp;Stolz,&nbsp;Hannah-Sophia&nbsp;Jauch,&nbsp;Hendrik&nbsp;Strumpf,&nbsp;Jens-Max&nbsp;Hopf,&nbsp;Constanze I.&nbsp;Seidenbecher,&nbsp;Bj\u00f6rn H.&nbsp;Schott,&nbsp;Anni&nbsp;Richter <span class=\"excerpt-magazin\">Aging Brain (2025)<\/span><\/p>\n<\/span>\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<article class=\"uagb-post__inner-wrap\">\t\t\t\t\t\t\t\t<h4 class=\"uagb-post__title uagb-post__text\">\n\t\t\t\t<a href=\"https:\/\/doi.org\/10.1016\/j.matbio.2025.01.001\" target=\"_blank\" rel=\"bookmark noopener noreferrer\">Neurocan regulates axon initial segment organization and neuronal activity<\/a>\n\t\t\t<\/h4>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t\t<time datetime=\"2025-01-07T13:50:52+01:00\" class=\"uagb-post__date\">\n\t\t\t\t<span class=\"dashicons-calendar dashicons\"><\/span>\t\t\t\t\t07.01.2025\t\t\t\t<\/time>\n\t\t\t\t\t\t\t<div class=\"uagb-post__text\">\n\t\t\t\t\t<span class='uagb-post__taxonomy'>\n\t\t\t\t\t\t<span class=\"dashicons-tag dashicons\"><\/span>\t\t\t\t\t\t<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a05-de\/\">A05<\/a>\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class='uagb-post__text uagb-post__excerpt'>\n\t\t\t\t\t<p>Baidoe-Ansah D, Mirzapourdelavar H, Aleshin S, Schott BH, Seidenbecher C, Kaushik R, Dityatev A. <span class=\"excerpt-magazin\">Matrix Biol. (2025)<\/span><\/p>\n<\/span>\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<article class=\"uagb-post__inner-wrap\">\t\t\t\t\t\t\t\t<h4 class=\"uagb-post__title uagb-post__text\">\n\t\t\t\t<a href=\"https:\/\/doi.org\/10.1038\/s41467-024-53360-9\" target=\"_blank\" rel=\"bookmark noopener noreferrer\">Kognitive Reserve gegen\u00fcber der Alzheimer-Pathologie ist mit der Gehirnaktivit\u00e4t w\u00e4hrend der Ged\u00e4chtnisbildung verbunden (2024)<\/a>\n\t\t\t<\/h4>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t\t<time datetime=\"2024-11-13T11:42:27+01:00\" class=\"uagb-post__date\">\n\t\t\t\t<span class=\"dashicons-calendar dashicons\"><\/span>\t\t\t\t\t13.11.2024\t\t\t\t<\/time>\n\t\t\t\t\t\t\t<div class=\"uagb-post__text\">\n\t\t\t\t\t<span class='uagb-post__taxonomy'>\n\t\t\t\t\t\t<span class=\"dashicons-tag dashicons\"><\/span>\t\t\t\t\t\t<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a04-de\/\">A04<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a05-de\/\">A05<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/b02-de\/\">B02<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/b04-de\/\">B04<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/c01-de\/\">C01<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/z03-de\/\">Z03<\/a>\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class='uagb-post__text uagb-post__excerpt'>\n\t\t\t\t\t<p>Niklas Vockert, Judith Machts, Luca Kleineidam, Aditya Nemali, Hartmut Sch\u00fctze, Renat Yakupov, Oliver Peters, Daria Gref, Luisa Sophie Schneider, Lukas Preis, Josef Priller, Eike Jakob Spruth, Slawek Altenstein, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Ayda Rostamzadeh, Wenzel Glanz, Enise I&#8230;.<\/span>\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<article class=\"uagb-post__inner-wrap\">\t\t\t\t\t\t\t\t<h4 class=\"uagb-post__title uagb-post__text\">\n\t\t\t\t<a href=\"https:\/\/doi.org\/10.1093\/brain\/awae149\" target=\"_blank\" rel=\"bookmark noopener noreferrer\">Single-value brain activity scores reflect both severity and risk across the Alzheimer&#8217;s continuum<\/a>\n\t\t\t<\/h4>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t\t<time datetime=\"2024-11-04T13:30:38+01:00\" class=\"uagb-post__date\">\n\t\t\t\t<span class=\"dashicons-calendar dashicons\"><\/span>\t\t\t\t\t04.11.2024\t\t\t\t<\/time>\n\t\t\t\t\t\t\t<div class=\"uagb-post__text\">\n\t\t\t\t\t<span class='uagb-post__taxonomy'>\n\t\t\t\t\t\t<span class=\"dashicons-tag dashicons\"><\/span>\t\t\t\t\t\t<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a04-de\/\">A04<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a05-de\/\">A05<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/b02-de\/\">B02<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/z03-de\/\">Z03<\/a>\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class='uagb-post__text uagb-post__excerpt'>\n\t\t\t\t\t<p>Niklas Soch J, Richter A, Kizilirmak JM, Sch\u00fctze H, Ziegler G, Altenstein S, Brosseron F, Fliessbach K, Freiesleben SD, Glanz W, Gref D, Heneka MT, Incesoy EI, Kilimann I, Kimmich O, Laske C, Lohse A, L\u00fcsebrink F, Munk MH, Peters&#8230;<\/span>\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<article class=\"uagb-post__inner-wrap\">\t\t\t\t\t\t\t\t<h4 class=\"uagb-post__title uagb-post__text\">\n\t\t\t\t<a href=\"https:\/\/doi.org\/10.1038\/d41586-024-02325-5\" target=\"_blank\" rel=\"bookmark noopener noreferrer\">Obesity is driven by a build-up of molecular mesh around hunger neurons<\/a>\n\t\t\t<\/h4>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t\t<time datetime=\"2024-09-18T13:57:21+02:00\" class=\"uagb-post__date\">\n\t\t\t\t<span class=\"dashicons-calendar dashicons\"><\/span>\t\t\t\t\t18.09.2024\t\t\t\t<\/time>\n\t\t\t\t\t\t\t<div class=\"uagb-post__text\">\n\t\t\t\t\t<span class='uagb-post__taxonomy'>\n\t\t\t\t\t\t<span class=\"dashicons-tag dashicons\"><\/span>\t\t\t\t\t\t<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a05-de\/\">A05<\/a>\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class='uagb-post__text uagb-post__excerpt'>\n\t\t\t\t\t<p>Alexander Dityatev <span class=\"excerpt-magazin\">Nature (2024)<\/span><\/p>\n<\/span>\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<article class=\"uagb-post__inner-wrap\">\t\t\t\t\t\t\t\t<h4 class=\"uagb-post__title uagb-post__text\">\n\t\t\t\t<a href=\"https:\/\/doi.org\/10.1162\/imag_a_00260\" target=\"_blank\" rel=\"bookmark noopener noreferrer\">Reduced expression of fMRI subsequent memory effects with increasing severity across the Alzheimer\u2019s disease risk spectrum<\/a>\n\t\t\t<\/h4>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t\t<time datetime=\"2024-08-20T13:33:26+02:00\" class=\"uagb-post__date\">\n\t\t\t\t<span class=\"dashicons-calendar dashicons\"><\/span>\t\t\t\t\t20.08.2024\t\t\t\t<\/time>\n\t\t\t\t\t\t\t<div class=\"uagb-post__text\">\n\t\t\t\t\t<span class='uagb-post__taxonomy'>\n\t\t\t\t\t\t<span class=\"dashicons-tag dashicons\"><\/span>\t\t\t\t\t\t<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a04-de\/\">A04<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a05-de\/\">A05<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/b02-de\/\">B02<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/z03-de\/\">Z03<\/a>\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class='uagb-post__text uagb-post__excerpt'>\n\t\t\t\t\t<p>Soch J, Richter A, Kizilirmak JM, Sch\u00fctze H, Altenstein S, Dechent P, Fliessbach K, Glanz W, Herrera AL, Hetzer S, Incesoy EI, Kilimann I, Kimmich O, Lammerding D, Laske C, Lohse A, L\u00fcsebrink F, Munk MH, Peters O, Preis L,&#8230;<\/span>\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<article class=\"uagb-post__inner-wrap\">\t\t\t\t\t\t\t\t<h4 class=\"uagb-post__title uagb-post__text\">\n\t\t\t\t<a href=\"https:\/\/doi.org\/10.1002\/glia.24596\" target=\"_blank\" rel=\"bookmark noopener noreferrer\">Astrocyte-derived factors regulate CNS myelination<\/a>\n\t\t\t<\/h4>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t\t<time datetime=\"2024-08-02T13:56:18+02:00\" class=\"uagb-post__date\">\n\t\t\t\t<span class=\"dashicons-calendar dashicons\"><\/span>\t\t\t\t\t02.08.2024\t\t\t\t<\/time>\n\t\t\t\t\t\t\t<div class=\"uagb-post__text\">\n\t\t\t\t\t<span class='uagb-post__taxonomy'>\n\t\t\t\t\t\t<span class=\"dashicons-tag dashicons\"><\/span>\t\t\t\t\t\t<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a05-de\/\">A05<\/a>\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class='uagb-post__text uagb-post__excerpt'>\n\t\t\t\t\t<p>Seiler S, Rudolf F, Gomes FR, Pavlovic A, Nebel J, Seidenbecher CI, Foo LC <span class=\"excerpt-magazin\">Glia (2024)<\/span><\/p>\n<\/span>\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<article class=\"uagb-post__inner-wrap\">\t\t\t\t\t\t\t\t<h4 class=\"uagb-post__title uagb-post__text\">\n\t\t\t\t<a href=\"https:\/\/doi.org\/10.1101\/2024.07.05.602082\" target=\"_blank\" rel=\"bookmark noopener noreferrer\">Frontal Theta Oscillations and Cognitive Flexibility: Age-Related Modulations in EEG Activity<\/a>\n\t\t\t<\/h4>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t\t<time datetime=\"2024-07-09T11:59:36+02:00\" class=\"uagb-post__date\">\n\t\t\t\t<span class=\"dashicons-calendar dashicons\"><\/span>\t\t\t\t\t09.07.2024\t\t\t\t<\/time>\n\t\t\t\t\t\t\t<div class=\"uagb-post__text\">\n\t\t\t\t\t<span class='uagb-post__taxonomy'>\n\t\t\t\t\t\t<span class=\"dashicons-tag dashicons\"><\/span>\t\t\t\t\t\t<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a05-de\/\">A05<\/a>\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class='uagb-post__text uagb-post__excerpt'>\n\t\t\t\t\t<p>Margarita Darna, Christopher Stolz, Hannah-Sophia Jauch, Hendrik Strumpf,&nbsp; Jens-Max Hopf,&nbsp; Constanze I. Seidenbecher,&nbsp; Bj\u00f6rn H. Schott,&nbsp; Anni Richter bioRxiv (2024)<\/p>\n<\/span>\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<article class=\"uagb-post__inner-wrap\">\t\t\t\t\t\t\t\t<h4 class=\"uagb-post__title uagb-post__text\">\n\t\t\t\t<a href=\"https:\/\/doi.org\/10.1016\/j.celrep.2024.114112\" target=\"_blank\" rel=\"bookmark noopener noreferrer\">Focal clusters of peri-synaptic matrix contribute to activity-dependent plasticity and memory in mice<\/a>\n\t\t\t<\/h4>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t\t<time datetime=\"2024-05-28T12:02:07+02:00\" class=\"uagb-post__date\">\n\t\t\t\t<span class=\"dashicons-calendar dashicons\"><\/span>\t\t\t\t\t28.05.2024\t\t\t\t<\/time>\n\t\t\t\t\t\t\t<div class=\"uagb-post__text\">\n\t\t\t\t\t<span class='uagb-post__taxonomy'>\n\t\t\t\t\t\t<span class=\"dashicons-tag dashicons\"><\/span>\t\t\t\t\t\t<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a05-de\/\">A05<\/a>\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class='uagb-post__text uagb-post__excerpt'>\n\t\t\t\t\t<p>Chelini G, Mirzapourdelavar H, Durning P, Baidoe-Ansah D, Sethi MK, O&#8217;Donovan SM, Klengel T, Balasco L, Berciu C, Boyer-Boiteau A, McCullumsmith R, Ressler KJ, Zaia J, Bozzi Y*, Dityatev A*, Berretta S*. <span class=\"excerpt-magazin\">Cell Rep (2024)<\/span><\/p>\n<\/span>\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<article class=\"uagb-post__inner-wrap\">\t\t\t\t\t\t\t\t<h4 class=\"uagb-post__title uagb-post__text\">\n\t\t\t\t<a href=\"https:\/\/doi.org\/10.1016\/j.matbio.2024.02.007\" target=\"_blank\" rel=\"bookmark noopener noreferrer\">Microvascular damage, neuroinflammation and extracellular matrix remodeling in Col18a1 knockout mice as a model for early cerebral small vessel disease<\/a>\n\t\t\t<\/h4>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t\t<time datetime=\"2024-02-21T22:48:00+01:00\" class=\"uagb-post__date\">\n\t\t\t\t<span class=\"dashicons-calendar dashicons\"><\/span>\t\t\t\t\t21.02.2024\t\t\t\t<\/time>\n\t\t\t\t\t\t\t<div class=\"uagb-post__text\">\n\t\t\t\t\t<span class='uagb-post__taxonomy'>\n\t\t\t\t\t\t<span class=\"dashicons-tag dashicons\"><\/span>\t\t\t\t\t\t<a href=\"https:\/\/sfb1436.de\/category\/publication\/a05\/\">A05<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a05-de\/\">A05<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/b04-de\/\">B04<\/a>\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class='uagb-post__text uagb-post__excerpt'>\n\t\t\t\t\t<p>Mahsima Khoshneviszadeh, Solveig Henneicke, Daniel Pirici, Akilashree Senthilnathan, Lorena Morton, Philipp Arndt, Rahul Kaushik, Oula Norman, Jari Jukkola, Ildiko Rita Dunay, Constanze Seidenbecher, Anne Heikkinen, Stefanie Schreiber *, Alexander Dityatev * <span class=\"excerpt-magazin\">Matrix Biol. (2024)<\/span><\/p>\n<\/span>\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<article class=\"uagb-post__inner-wrap\">\t\t\t\t\t\t\t\t<h4 class=\"uagb-post__title uagb-post__text\">\n\t\t\t\t<a href=\"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2023.12.002\" target=\"_blank\" rel=\"bookmark noopener noreferrer\">Age-related differences in fMRI subsequent memory effects are directly linked to local grey matter volume differences<\/a>\n\t\t\t<\/h4>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t\t<time datetime=\"2024-02-12T13:41:47+01:00\" class=\"uagb-post__date\">\n\t\t\t\t<span class=\"dashicons-calendar dashicons\"><\/span>\t\t\t\t\t12.02.2024\t\t\t\t<\/time>\n\t\t\t\t\t\t\t<div class=\"uagb-post__text\">\n\t\t\t\t\t<span class='uagb-post__taxonomy'>\n\t\t\t\t\t\t<span class=\"dashicons-tag dashicons\"><\/span>\t\t\t\t\t\t<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a05-de\/\">A05<\/a>\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class='uagb-post__text uagb-post__excerpt'>\n\t\t\t\t\t<p>Kizilirmak JM, Soch J, Richter A, Schott BH <span class=\"excerpt-magazin\">Neurobiol Aging (2024)<\/span><\/p>\n<\/span>\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<article class=\"uagb-post__inner-wrap\">\t\t\t\t\t\t\t\t<h4 class=\"uagb-post__title uagb-post__text\">\n\t\t\t\t<a href=\"https:\/\/doi.org\/10.1101\/2024.01.26.577401\" target=\"_blank\" rel=\"bookmark noopener noreferrer\">Neurocan regulates axon initial segment organization and neuronal activity in cultured cortical neurons<\/a>\n\t\t\t<\/h4>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t\t<time datetime=\"2024-01-26T13:53:25+01:00\" class=\"uagb-post__date\">\n\t\t\t\t<span class=\"dashicons-calendar dashicons\"><\/span>\t\t\t\t\t26.01.2024\t\t\t\t<\/time>\n\t\t\t\t\t\t\t<div class=\"uagb-post__text\">\n\t\t\t\t\t<span class='uagb-post__taxonomy'>\n\t\t\t\t\t\t<span class=\"dashicons-tag dashicons\"><\/span>\t\t\t\t\t\t<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a05-de\/\">A05<\/a>\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class='uagb-post__text uagb-post__excerpt'>\n\t\t\t\t\t<p>Baidoe-Ansah D, Mirzapourdelavar H, Aleshin S, Schott BH, Seidenbecher CI, Kaushik R, Dityatev A. <span class=\"excerpt-magazin\">bioRxiv (2024)<\/span><\/p>\n<\/span>\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<article class=\"uagb-post__inner-wrap\">\t\t\t\t\t\t\t\t<h4 class=\"uagb-post__title uagb-post__text\">\n\t\t\t\t<a href=\"https:\/\/doi.org\/10.1101\/2023.10.10.561675\" target=\"_blank\" rel=\"bookmark noopener noreferrer\">Kognitive Reserve gegen\u00fcber der Alzheimer-Pathologie ist mit der Gehirnaktivit\u00e4t w\u00e4hrend der Ged\u00e4chtnisbildung verbunden (2023)<\/a>\n\t\t\t<\/h4>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t\t<time datetime=\"2023-10-13T23:36:00+02:00\" class=\"uagb-post__date\">\n\t\t\t\t<span class=\"dashicons-calendar dashicons\"><\/span>\t\t\t\t\t13.10.2023\t\t\t\t<\/time>\n\t\t\t\t\t\t\t<div class=\"uagb-post__text\">\n\t\t\t\t\t<span class='uagb-post__taxonomy'>\n\t\t\t\t\t\t<span class=\"dashicons-tag dashicons\"><\/span>\t\t\t\t\t\t<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a05-de\/\">A05<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/b02-de\/\">B02<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/b04-de\/\">B04<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/c01-de\/\">C01<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/z03-de\/\">Z03<\/a>\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class='uagb-post__text uagb-post__excerpt'>\n\t\t\t\t\t<p>Niklas Vockert, Judith Machts, Luca Kleineidam, Aditya Nemali, Hartmut Sch\u00fctze, Renat Yakupov, Oliver Peters, Daria Gref, Luisa Sophie Schneider, Lukas Preis, Josef Priller, Eike Jakob Spruth, Slawek Altenstein, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Ayda Rostamzadeh, Wenzel Glanz, Enise I&#8230;.<\/span>\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<article class=\"uagb-post__inner-wrap\">\t\t\t\t\t\t\t\t<h4 class=\"uagb-post__title uagb-post__text\">\n\t\t\t\t<a href=\"https:\/\/doi.org\/10.1016\/j.nbd.2023.106324\" target=\"_blank\" rel=\"bookmark noopener noreferrer\">Linking epileptic phenotypes and neural extracellular matrix remodeling signatures in mouse models of epilepsy<\/a>\n\t\t\t<\/h4>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t\t<time datetime=\"2023-10-12T13:37:17+02:00\" class=\"uagb-post__date\">\n\t\t\t\t<span class=\"dashicons-calendar dashicons\"><\/span>\t\t\t\t\t12.10.2023\t\t\t\t<\/time>\n\t\t\t\t\t\t\t<div class=\"uagb-post__text\">\n\t\t\t\t\t<span class='uagb-post__taxonomy'>\n\t\t\t\t\t\t<span class=\"dashicons-tag dashicons\"><\/span>\t\t\t\t\t\t<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a05-de\/\">A05<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a07-de\/\">A07<\/a>\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class='uagb-post__text uagb-post__excerpt'>\n\t\t\t\t\t<p>Armand Blondiaux, Shaobo Jia, Anil Annamneedi, G\u00fcrsel \u00c7al\u0131\u015fkan, Jana Nebel, Carolina Montenegro-Venegas, Robert C Wykes, Anna Fejtova, Matthew C Walker, Oliver Stork, Eckart D Gundelfinger, Alexander Dityatev, Constanze I Seidenbecher <span class=\"excerpt-magazin\">Neurobiol Dis (2023)<\/span><\/p>\n<\/span>\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<article class=\"uagb-post__inner-wrap\">\t\t\t\t\t\t\t\t<h4 class=\"uagb-post__title uagb-post__text\">\n\t\t\t\t<a href=\"https:\/\/doi.org\/10.1016\/j.isci.2023.107765\" target=\"_blank\" rel=\"bookmark noopener noreferrer\">Inhibitory temporo-parietal effective connectivity is associated with explicit memory performance in older adults<\/a>\n\t\t\t<\/h4>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t\t<time datetime=\"2023-08-29T10:18:28+02:00\" class=\"uagb-post__date\">\n\t\t\t\t<span class=\"dashicons-calendar dashicons\"><\/span>\t\t\t\t\t29.08.2023\t\t\t\t<\/time>\n\t\t\t\t\t\t\t<div class=\"uagb-post__text\">\n\t\t\t\t\t<span class='uagb-post__taxonomy'>\n\t\t\t\t\t\t<span class=\"dashicons-tag dashicons\"><\/span>\t\t\t\t\t\t<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a05-de\/\">A05<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/b01-de\/\">B01<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/b04-de\/\">B04<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/c01-de\/\">C01<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/z03-de\/\">Z03<\/a>\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class='uagb-post__text uagb-post__excerpt'>\n\t\t\t\t\t<p>Schott BH, Soch J, Kizilirmak JM, Sch\u00fctze H, Assmann A, Maass A, Ziegler G, Sauvage M, Richter A. <span class=\"excerpt-magazin\">iScience (2023)<\/span><\/p>\n<\/span>\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<article class=\"uagb-post__inner-wrap\">\t\t\t\t\t\t\t\t<h4 class=\"uagb-post__title uagb-post__text\">\n\t\t\t\t<a href=\"https:\/\/doi.org\/10.1093\/scan\/nsad041\" target=\"_blank\" rel=\"bookmark noopener noreferrer\">Openness to Experience is associated with neural and performance measures of memory in older adults<\/a>\n\t\t\t<\/h4>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t\t<time datetime=\"2023-08-26T13:43:00+02:00\" class=\"uagb-post__date\">\n\t\t\t\t<span class=\"dashicons-calendar dashicons\"><\/span>\t\t\t\t\t26.08.2023\t\t\t\t<\/time>\n\t\t\t\t\t\t\t<div class=\"uagb-post__text\">\n\t\t\t\t\t<span class='uagb-post__taxonomy'>\n\t\t\t\t\t\t<span class=\"dashicons-tag dashicons\"><\/span>\t\t\t\t\t\t<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a05-de\/\">A05<\/a>\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class='uagb-post__text uagb-post__excerpt'>\n\t\t\t\t\t<p>Stolz C, Bulla A, Soch J, Schott BH, Richter A <span class=\"excerpt-magazin\">Soc Cogn Affect Neurosci (2023)<\/span><\/p>\n<\/span>\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-19fccbcd wp-block-buttons-is-layout-flex\" style=\"margin-top:40px;margin-bottom:0px\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link has-project-c-color has-white-background-color has-text-color has-background wp-element-button\" href=\"https:\/\/sfb1436.de\/de\/publikationen\/\">Alle Publikationen<\/a><\/div>\n\n\n\n<div class=\"wp-block-button is-style-outline is-style-outline--1\"><a class=\"wp-block-button__link has-white-color has-text-color wp-element-button\" href=\"https:\/\/sfb1436.de\/de\/projekte\/\">Alle Projekte<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Wir untersuchen, wie die extrazellul\u00e4re Matrix (ECM) des Gehirns zu kognitiver Flexibilit\u00e4t (CFL) und Ged\u00e4chtnis bei M\u00e4usen und Menschen beitr\u00e4gt. Mit molekularen Tools werden wir die ECM modifizieren und CFL, Enkodierungs- sowie Ged\u00e4chtnisprozesse bei M\u00e4usen untersuchen und beim Menschen analoge Ma\u00dfe mit peripheren ECM-Markern korrelieren. Diffusions- und quantitative Suszeptibilit\u00e4ts-Bildgebung wollen wir als MRT-basierte Ma\u00dfe f\u00fcr [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":0,"parent":3279,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_crdt_document":"","_uag_custom_page_level_css":"","footnotes":""},"class_list":["post-7080","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>A05 - Integrit\u00e4t der Extrazellul\u00e4rmatrix<\/title>\n<meta name=\"description\" content=\"Wir untersuchen, wie die extrazellul\u00e4re Matrix (ECM) des Gehirns zu kognitiver Flexibilit\u00e4t (CFL) und Ged\u00e4chtnis bei M\u00e4usen und Menschen...\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sfb1436.de\/de\/projekte\/integritaet-der-extrazellulaermatrix-als-neurale-ressource-fuer-gedaechtnis-praezision-und-kognitive-flexibilitaet\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A05 - 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