{"id":6971,"date":"2022-02-16T15:24:29","date_gmt":"2022-02-16T14:24:29","guid":{"rendered":"https:\/\/sfb1436.de\/menue-1\/neural-resource-allocation-by-spatial-memory-circuits-facing-progressive-pathological-challenges\/"},"modified":"2025-05-19T06:29:46","modified_gmt":"2025-05-19T04:29:46","slug":"a03-theta-aktivitaet-dekodierung-inhibitorischer-schaltkreise-in-der-alzheimer-maus-mensch-forschung","status":"publish","type":"page","link":"https:\/\/sfb1436.de\/de\/projekte\/a03-theta-aktivitaet-dekodierung-inhibitorischer-schaltkreise-in-der-alzheimer-maus-mensch-forschung\/","title":{"rendered":"A03 &#8211; Theta Aktivit\u00e4t: Dekodierung inhibitorischer Schaltkreise in der Alzheimer-Maus-Mensch-Forschung"},"content":{"rendered":"\n<div class=\"wp-block-uagb-section uagb-section__wrap uagb-section__background-color uagb-block-1d647f26 badge-title\"><div class=\"uagb-section__overlay\"><\/div><div class=\"uagb-section__inner-wrap\">\n<p class=\"has-text-align-center wp-block-paragraph\">A03<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group alignwide has-white-background-color has-background is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-columns are-vertically-aligned-center is-layout-flex wp-container-core-columns-is-layout-147ade55 wp-block-columns-is-layout-flex\" style=\"padding-top:0px;padding-bottom:0px\">\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:20px;padding-right:20px;padding-bottom:20px;padding-left:20px\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><a href=\"https:\/\/sfb1436.de\/wp-content\/uploads\/2025\/01\/A03_25-28_abstract.jpg\"><img fetchpriority=\"high\" decoding=\"async\" width=\"724\" height=\"550\" src=\"https:\/\/sfb1436.de\/wp-content\/uploads\/2025\/01\/A03_25-28_abstract.jpg\" alt=\"Graphical Abstract - Projekt A03 2025-2028\" class=\"wp-image-25067\" style=\"width:419px;height:auto\"\/><\/a><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-left wp-block-paragraph\">Unser Maus-Mensch-Projekt untersucht, wie Beeintr\u00e4chtigungen in inhibitorischen Mikroschaltkreisen w\u00e4hrend Theta-Phasen die Verarbeitung von Umgebungsinformationen, besonders in Alzheimer-Modellen, beeinflussen. Wir konzentrieren uns auf verschiedene inhibitorische Schaltkreise und ihre Auswirkungen auf kognitive Funktionen wie Ged\u00e4chtnisencodierung und -abruf. Durch den Einsatz von hAPP-Mausmodellen erforschen wir, wie Beta-Amyloidose diese Schaltkreise st\u00f6rt und zu Ged\u00e4chtnisdefiziten beitr\u00e4gt. An MCI Patienten zeigen wir wie Locomotion kognitiven Einschr\u00e4nkungen entgegenwirkt. Unsere Studie zielt auch auf potenzielle therapeutische Ziele, um wichtige neuronale Mechanismen der kognitiven Beeintr\u00e4chtigung bei Alzheimer aufzudecken.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns are-vertically-aligned-top is-layout-flex wp-container-core-columns-is-layout-43c3a9c5 wp-block-columns-is-layout-flex\" id=\"project-anchor\" style=\"padding-top:0px;padding-bottom:30px\">\n<div class=\"wp-block-column is-vertically-aligned-top is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-f56f613f wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" id=\"projekt\">\n<div class=\"wp-block-buttons is-horizontal is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-b0be8b0e wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button has-custom-width wp-block-button__width-100 is-style-fill\"><a class=\"wp-block-button__link has-white-color has-project-c-background-color has-text-color has-background has-normal-font-size has-custom-font-size wp-element-button\" href=\"#unsere-forschung\"><strong>Unsere Forschung<\/strong><\/a><\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" id=\"projekt\">\n<div class=\"wp-block-buttons is-horizontal is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-b0be8b0e wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button has-custom-width wp-block-button__width-100 is-style-fill\"><a class=\"wp-block-button__link has-white-color has-secondary-background-color has-text-color has-background has-normal-font-size has-custom-font-size wp-element-button\" href=\"#ziele\"><strong>Ziele unseres Projektes<\/strong><\/a><\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" id=\"projekt\">\n<div class=\"wp-block-buttons is-horizontal is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-b0be8b0e wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button has-custom-width wp-block-button__width-100 is-style-fill\"><a class=\"wp-block-button__link has-white-color has-project-c-background-color has-text-color has-background has-normal-font-size has-custom-font-size wp-element-button\" href=\"#publications\"><strong>Publikationen<\/strong><\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns alignfull has-tertiary-background-color has-background is-layout-flex wp-container-core-columns-is-layout-763026b3 wp-block-columns-is-layout-flex\" style=\"margin-top:0px;margin-bottom:0px\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" id=\"pi\">\n<h2 class=\"wp-block-heading has-text-align-center\" id=\"gruppenleitung\" style=\"font-style:normal;font-weight:500\">Gruppenleitung<\/h2>\n\n\n<div id=\"awsm-team-25068\" class=\"awsm-grid-wrapper\">\n\t\t\n\t\t<div class=''>\n\t\t<div class=\"gridder awsm-grid drawer-style style-1 grid-2-col \">\n\t\t\t\t\t\t<div id=\"awsm-member-25068-3633\" class=\"awsm-grid-list awsm-grid-card awsm-team-item awsm-scale-anm awsm-all\" data-griddercontent=\"#awsm-grid-content-3633\">\n\t\t\t\t\t<span class=\"awsm-team-link-control awsm-grid-list-item awsm-grid-list-item-3633\" data-info=\"3633\">\n\t\t\t\t\t\t<figure>\n\t\t\t\t\t\t<img decoding=\"async\" width=\"800\" height=\"1000\" src=\"https:\/\/sfb1436.de\/wp-content\/uploads\/2022\/02\/20210526-232-Dr.-Stefan-Duerschmidt_web-800x1000.jpg\" class=\"attachment-awsm_team size-awsm_team wp-post-image\" alt=\"SFB 1436 Mitglied Stefan D\u00fcrschmid\" \/>\t\t\t\t\t\t\t<figcaption>\n\t\t\t\t\t\t\t\t<div class=\"awsm-personal-info\"><span><\/span><h3>Dr. Stefan D\u00fcrschmid<\/h3><\/div>\t\t\t\t\t\t\t<\/figcaption>\n\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div id=\"awsm-member-25068-3722\" class=\"awsm-grid-list awsm-grid-card awsm-team-item awsm-scale-anm awsm-all\" data-griddercontent=\"#awsm-grid-content-3722\">\n\t\t\t\t\t<span class=\"awsm-team-link-control awsm-grid-list-item awsm-grid-list-item-3722\" data-info=\"3722\">\n\t\t\t\t\t\t<figure>\n\t\t\t\t\t\t<img decoding=\"async\" width=\"800\" height=\"714\" src=\"https:\/\/sfb1436.de\/wp-content\/uploads\/2022\/02\/20210217-Remy-001_web-800x714.jpg\" class=\"attachment-awsm_team size-awsm_team wp-post-image\" alt=\"SFB 1436 Mitglied Stefan Remy\" \/>\t\t\t\t\t\t\t<figcaption>\n\t\t\t\t\t\t\t\t<div class=\"awsm-personal-info\"><span><\/span><h3>Prof. Dr. med. Stefan Remy<\/h3><\/div>\t\t\t\t\t\t\t<\/figcaption>\n\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<div class=\"awsm-grid-expander style-1\">\n\t\t\t\t\t\t<div id=\"awsm-member-info-25068-3633\"  class=\"awsm-grid-expander style-1\">\n\t\t\t\t<div class=\"awsm-detailed-info\" id=\"awsm-grid-content-3633\">\n\t\t\t\t\t<div class=\"awsm-details\">\n\t\t\t\t\t\t<div class=\"awsm-personal-details\">\n\t\t\t\t\t\t\t<div class=\"awsm-content-scrollbar\">\n\t\t\t\t\t\t\t\t<span><\/span><h2>Dr. Stefan D\u00fcrschmid<\/h2>\n<p class=\"wp-block-paragraph\">Stefan D\u00fcrschmid erhielt ein Diplom in P\u00e4dagogik (2005) und Psychologie (2009). 2013 beendete sein PhD und war als visiting scholar an der UC Berkeley (2013-2014). Er ist Leiter der Forschungsgruppe \u201eSensorisches Lernen und Vorhersagen\u201c und reichte 2021 seine Habilitationsschrift an der Otto-von-Guericke Universit\u00e4t ein.<\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"awsm-personal-contact-info\">\n\t\t\t\t\t   <div class=\"awsm-contact-details\"><p><span>Institut:<\/span> <a href=\"https:\/\/www.lin-magdeburg.de\/\" target=\"_blank\">Leibniz-Institut f\u00fcr Neurobiologie (LIN) Magdeburg<\/a><\/p><p><span>Project Title:<\/span><a href=\"https:\/\/sfb1436.de\/de\/projekte\/a03-theta-aktivitaet-dekodierung-inhibitorischer-schaltkreise-in-der-alzheimer-maus-mensch-forschung\/\" target=\"_blank\"><b>A03<\/b> Theta Aktivit\u00e4t: Dekodierung inhibitorischer Schaltkreise in der Alzheimer-Maus-Mensch-Forschung<\/a><\/p><\/div><div class=\"awsm-social-icons\"><span><a href=\"mailto:&#039;stefan.duerschmid@lin-magdeburg.de\"><i class=\"awsm-icon-mail\" aria-hidden=\"true\"><\/i><\/a><\/span><span><a href=\"tel:+49-391-6263-92311\" target=\"_blank\"><i class=\"awsm-icon-phone\" aria-hidden=\"true\"><\/i><\/a><\/span><span><a href=\"https:\/\/www.lin-magdeburg.de\/forschung\/abteilung-verhaltensneurologie\/ag-sensorisches-lernen-und-prognose\" target=\"_blank\"><i class=\"awsm-icon-link\" aria-hidden=\"true\"><\/i><\/a><\/span><span><a href=\"https:\/\/twitter.com\/duerschmid?lang=de\" target=\"_blank\"><i class=\"awsm-icon-twitter\" aria-hidden=\"true\"><\/i><\/a><\/span><\/div>\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<div id=\"awsm-member-info-25068-3722\"  class=\"awsm-grid-expander style-1\">\n\t\t\t\t<div class=\"awsm-detailed-info\" id=\"awsm-grid-content-3722\">\n\t\t\t\t\t<div class=\"awsm-details\">\n\t\t\t\t\t\t<div class=\"awsm-personal-details\">\n\t\t\t\t\t\t\t<div class=\"awsm-content-scrollbar\">\n\t\t\t\t\t\t\t\t<span><\/span><h2>Prof. Dr. med. Stefan Remy<\/h2>\n<p class=\"wp-block-paragraph\">Stefan Remy ist der wissenschaftliche Direktor des LIN, leitet die Abteilung Zellul\u00e4re Neurowissenschaft und ist Professor f\u00fcr molekulare und zellul\u00e4re Neurowissenschaft an der medizinischen Fakult\u00e4t der Otto-von-Guericke-Universit\u00e4t in Magdeburg. Er promovierte im Jahr 2003 an der Universit\u00e4t Bonn und forschte im Anschluss als Postdoktorand bei Heinz Beck an der Klinik f\u00fcr Epileptologie (Direktor: Christian E. Elger). Als Alexander von Humboldt-Stipendiat schloss er sich dem Department f\u00fcr Neurobiologie und Physiologe an der Northwestern University in Evanston, USA, an. Dort forschte er bei Nelson Spruston an synaptischer Plastizit\u00e4t und neuronaler Erregbarkeit. Im Jahr 2007 setzte er seine Forschungen mit Heinz Beck in Bonn fort, dort gr\u00fcndete er im Jahr 2009 seine eigene Forschungsgruppe, gef\u00f6rdert durch das Land Nordrhein-Westfalen. Bevor er im Jahr 2020 seine neuen Aufgaben am LIN antrat, forschte er 10 Jahre als Leiter der Arbeitsgruppe \u201eNeuronale Netzwerke\u201c am Deutschen Zentrum f\u00fcr Neurodegenerative Erkrankungen Bonn. Stefan Remy ist Sprecher des Center for Behavioral Brain Sciences (CBBS) und vertritt den Standort Magdeburg (im Verbund Jena-Magdeburg- Halle) am neu gegr\u00fcndeten Deutschen Zentrum f\u00fcr psychische Gesundheit.<\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"awsm-personal-contact-info\">\n\t\t\t\t\t   <div class=\"awsm-contact-details\"><p><span>Institut:<\/span><a href=\"https:\/\/www.lin-magdeburg.de\/\" target=\"_blank\">Leibniz-Institut\u00a0f\u00fcr Neurobiologie (LIN)\u00a0Magdeburg<\/a><\/p><p><span>Project Title:<\/span><a href=\"https:\/\/sfb1436.de\/de\/projekte\/a03-theta-aktivitaet-dekodierung-inhibitorischer-schaltkreise-in-der-alzheimer-maus-mensch-forschung\/\" target=\"_blank\"><b>A03<\/b> Theta Aktivit\u00e4t: Dekodierung inhibitorischer Schaltkreise in der Alzheimer-Maus-Mensch-Forschung<\/a><\/p><\/div><div class=\"awsm-social-icons\"><span><a href=\"mailto:Stefan.Remy@lin-magdeburg.de\"><i class=\"awsm-icon-mail\" aria-hidden=\"true\"><\/i><\/a><\/span><span><a href=\"tel:+49-391-6263-92411\" target=\"_blank\"><i class=\"awsm-icon-phone\" aria-hidden=\"true\"><\/i><\/a><\/span><span><a href=\"https:\/\/www.lin-magdeburg.de\/forschung\/forschungseinheiten\/abteilung-zellulaere-neurowissenschaften\" target=\"_blank\"><i class=\"awsm-icon-link\" aria-hidden=\"true\"><\/i><\/a><\/span><\/div>\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t<\/div>\n\t<\/div>\n\n\n\n\n<div class=\"wp-block-columns justify-content-center is-layout-flex wp-container-core-columns-is-layout-f56f613f wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:1350px\">\n<h2 class=\"wp-block-heading has-text-align-center\" id=\"gruppenmitglieder\" style=\"font-style:normal;font-weight:500\">Gruppenmitglieder<\/h2>\n\n\n<div id=\"awsm-team-25069\" class=\"awsm-grid-wrapper\">\n\t\t\n\t\t<div class=''>\n\t\t<div class=\"gridder awsm-grid drawer-style style-1 grid-2-col \">\n\t\t\t\t\t\t<div id=\"awsm-member-25069-14254\" class=\"awsm-grid-list awsm-grid-card awsm-team-item awsm-scale-anm awsm-all\" data-griddercontent=\"#awsm-grid-content-14254\">\n\t\t\t\t\t<span class=\"awsm-team-link-control awsm-grid-list-item awsm-grid-list-item-14254\" data-info=\"14254\">\n\t\t\t\t\t\t<figure>\n\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"1000\" src=\"https:\/\/sfb1436.de\/wp-content\/uploads\/2022\/05\/20211102-0804-Xinyun-Che-800x1000.jpg\" class=\"attachment-awsm_team size-awsm_team wp-post-image\" alt=\"CRC 1436 member Xinyun Che\" \/>\t\t\t\t\t\t\t<figcaption>\n\t\t\t\t\t\t\t\t<div class=\"awsm-personal-info\"><span><\/span><h3>Xinyun Che<\/h3><\/div>\t\t\t\t\t\t\t<\/figcaption>\n\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div id=\"awsm-member-25069-3671\" class=\"awsm-grid-list awsm-grid-card awsm-team-item awsm-scale-anm awsm-all\" data-griddercontent=\"#awsm-grid-content-3671\">\n\t\t\t\t\t<span class=\"awsm-team-link-control awsm-grid-list-item awsm-grid-list-item-3671\" data-info=\"3671\">\n\t\t\t\t\t\t<figure>\n\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"785\" src=\"https:\/\/sfb1436.de\/wp-content\/uploads\/2022\/01\/no-image-men-4.png\" class=\"attachment-awsm_team size-awsm_team wp-post-image\" alt=\"Platzhalter SFB 1436 Magdeburg Mitglieder kein Foto\" \/>\t\t\t\t\t\t\t<figcaption>\n\t\t\t\t\t\t\t\t<div class=\"awsm-personal-info\"><span><\/span><h3>Dr. Hiroshi Kaneko<\/h3><\/div>\t\t\t\t\t\t\t<\/figcaption>\n\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div id=\"awsm-member-25069-3686\" class=\"awsm-grid-list awsm-grid-card awsm-team-item awsm-scale-anm awsm-all\" data-griddercontent=\"#awsm-grid-content-3686\">\n\t\t\t\t\t<span class=\"awsm-team-link-control awsm-grid-list-item awsm-grid-list-item-3686\" data-info=\"3686\">\n\t\t\t\t\t\t<figure>\n\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"1000\" src=\"https:\/\/sfb1436.de\/wp-content\/uploads\/2022\/05\/20211102-0936-Felix-Kuhn-800x1000.jpg\" class=\"attachment-awsm_team size-awsm_team wp-post-image\" alt=\"SFB 1436 Mitglied Felix Kuhn\" \/>\t\t\t\t\t\t\t<figcaption>\n\t\t\t\t\t\t\t\t<div class=\"awsm-personal-info\"><span><\/span><h3>Felix Kuhn<\/h3><\/div>\t\t\t\t\t\t\t<\/figcaption>\n\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div id=\"awsm-member-25069-25973\" class=\"awsm-grid-list awsm-grid-card awsm-team-item awsm-scale-anm awsm-all\" data-griddercontent=\"#awsm-grid-content-25973\">\n\t\t\t\t\t<span class=\"awsm-team-link-control awsm-grid-list-item awsm-grid-list-item-25973\" data-info=\"25973\">\n\t\t\t\t\t\t<figure>\n\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"780\" src=\"https:\/\/sfb1436.de\/wp-content\/uploads\/2022\/01\/no-image-woman-1.png\" class=\"attachment-awsm_team size-awsm_team wp-post-image\" alt=\"Platzhalter SFB 1436 Magdeburg Mitglieder kein Foto\" \/>\t\t\t\t\t\t\t<figcaption>\n\t\t\t\t\t\t\t\t<div class=\"awsm-personal-info\"><span><\/span><h3>Dr. Liudmila Sosulina<\/h3><\/div>\t\t\t\t\t\t\t<\/figcaption>\n\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<div class=\"awsm-grid-expander style-1\">\n\t\t\t\t\t\t<div id=\"awsm-member-info-25069-14254\"  class=\"awsm-grid-expander style-1\">\n\t\t\t\t<div class=\"awsm-detailed-info\" id=\"awsm-grid-content-14254\">\n\t\t\t\t\t<div class=\"awsm-details\">\n\t\t\t\t\t\t<div class=\"awsm-personal-details\">\n\t\t\t\t\t\t\t<div class=\"awsm-content-scrollbar\">\n\t\t\t\t\t\t\t\t<span><\/span><h2>Xinyun Che<\/h2>\n<p class=\"wp-block-paragraph\">Xinyun Che studierte an der China Agriculture University Biologie. 2019 erhielt sie ihren Master-Abschluss in Biotechnologie an der University of Queensland. Bevor sie 2021 ihr Promotionsstudium am Leibniz-Institut f\u00fcr Neurobiologie in Magdeburg begann, arbeitete sie ein Jahr lang als Forschungstechnikerin an der Chinesischen Akademie der Wissenschaften.<\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"awsm-personal-contact-info\">\n\t\t\t\t\t   <div class=\"awsm-contact-details\"><p><span>Institut:<\/span><a href=\"https:\/\/www.lin-magdeburg.de\/\" target=\"_blank\">Leibniz-Institut f\u00fcr Neurobiologie (LIN) Magdeburg<\/a><\/p><p><span>Projekt:<\/span><a href=\"https:\/\/sfb1436.de\/de\/projekte\/a03-theta-aktivitaet-dekodierung-inhibitorischer-schaltkreise-in-der-alzheimer-maus-mensch-forschung\/\" target=\"_blank\"><b>A03<\/b> Theta Aktivit\u00e4t: Dekodierung inhibitorischer Schaltkreise in der Alzheimer-Maus-Mensch-Forschung<\/a><\/p><\/div><div class=\"awsm-social-icons\"><span><a href=\"mailto:xinyun.che@lin-magdeburg.de\"><i class=\"awsm-icon-mail\" aria-hidden=\"true\"><\/i><\/a><\/span><span><a href=\"https:\/\/www.lin-magdeburg.de\/forschung\/abteilung-verhaltensneurologie\/ag-sensorisches-lernen-und-prognose\" target=\"_blank\"><i class=\"awsm-icon-link\" aria-hidden=\"true\"><\/i><\/a><\/span><\/div>\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<div id=\"awsm-member-info-25069-3671\"  class=\"awsm-grid-expander style-1\">\n\t\t\t\t<div class=\"awsm-detailed-info\" id=\"awsm-grid-content-3671\">\n\t\t\t\t\t<div class=\"awsm-details\">\n\t\t\t\t\t\t<div class=\"awsm-personal-details\">\n\t\t\t\t\t\t\t<div class=\"awsm-content-scrollbar\">\n\t\t\t\t\t\t\t\t<span><\/span><h2>Dr. Hiroshi Kaneko<\/h2>\n<p class=\"wp-block-paragraph\">coming soon<\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"awsm-personal-contact-info\">\n\t\t\t\t\t   <div class=\"awsm-contact-details\"><p><span>:<\/span><a href=\"https:\/\/www.lin-magdeburg.de\/\" target=\"_blank\">Leibniz-Institut f\u00fcr Neurobiologie (LIN) Magdeburg<\/a><\/p><p><span>Project:<\/span><a href=\"https:\/\/sfb1436.de\/de\/projekte\/a03-theta-aktivitaet-dekodierung-inhibitorischer-schaltkreise-in-der-alzheimer-maus-mensch-forschung\/\" target=\"_blank\"><b>A03<\/b> Theta Aktivit\u00e4t: Dekodierung inhibitorischer Schaltkreise in der Alzheimer-Maus-Mensch-Forschung<\/a><\/p><\/div><div class=\"awsm-social-icons\"><span><a href=\"mailto:Hiroshi.Kaneko@lin-magdeburg.de\"><i class=\"awsm-icon-mail\" aria-hidden=\"true\"><\/i><\/a><\/span><span><a href=\"https:\/\/www.lin-magdeburg.de\/forschung\/forschungseinheiten\/abteilung-zellulaere-neurowissenschaften\" target=\"_blank\"><i class=\"awsm-icon-link\" aria-hidden=\"true\"><\/i><\/a><\/span><\/div>\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<div id=\"awsm-member-info-25069-3686\"  class=\"awsm-grid-expander style-1\">\n\t\t\t\t<div class=\"awsm-detailed-info\" id=\"awsm-grid-content-3686\">\n\t\t\t\t\t<div class=\"awsm-details\">\n\t\t\t\t\t\t<div class=\"awsm-personal-details\">\n\t\t\t\t\t\t\t<div class=\"awsm-content-scrollbar\">\n\t\t\t\t\t\t\t\t<span><\/span><h2>Felix Kuhn<\/h2>\n<p class=\"wp-block-paragraph\">Felix Kuhn studierte Physik an der Universit\u00e4t W\u00fcrzburg, wo er 2018 seinen Bachelorabschluss erhielt. 2021 schloss er den Masterstudiengang Integrative Neuroscience an der Otto-von-Guericke-Universit\u00e4t Magdeburg ab. Seine Masterarbeit schrieb er in der Forschungsgruppe f\u00fcr Vergleichenden Neurowissenschaften am Leibniz-Institut f\u00fcr Neurobiologie und arbeitet nun als Doktorand in der Abteilung Zellul\u00e4re Neurowissenschaften.<\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"awsm-personal-contact-info\">\n\t\t\t\t\t   <div class=\"awsm-contact-details\"><p><span>Institut:<\/span><a href=\"https:\/\/www.lin-magdeburg.de\/\" target=\"_blank\">Leibniz-Institut\u00a0f\u00fcr Neurobiologie (LIN)\u00a0Magdeburg<\/a><\/p><p><span>Projekt:<\/span><a href=\"https:\/\/sfb1436.de\/de\/projekte\/a03-theta-aktivitaet-dekodierung-inhibitorischer-schaltkreise-in-der-alzheimer-maus-mensch-forschung\/\" target=\"_blank\"><b>A03<\/b> Theta Aktivit\u00e4t: Dekodierung inhibitorischer Schaltkreise in der Alzheimer-Maus-Mensch-Forschung<\/a><\/p><\/div><div class=\"awsm-social-icons\"><span><a href=\"mailto:felix.kuhn@lin-magdeburg.de\"><i class=\"awsm-icon-mail\" aria-hidden=\"true\"><\/i><\/a><\/span><span><a href=\"https:\/\/www.lin-magdeburg.de\/forschung\/forschungseinheiten\/abteilung-zellulaere-neurowissenschaften\" target=\"_blank\"><i class=\"awsm-icon-link\" aria-hidden=\"true\"><\/i><\/a><\/span><\/div>\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<div id=\"awsm-member-info-25069-25973\"  class=\"awsm-grid-expander style-1\">\n\t\t\t\t<div class=\"awsm-detailed-info\" id=\"awsm-grid-content-25973\">\n\t\t\t\t\t<div class=\"awsm-details\">\n\t\t\t\t\t\t<div class=\"awsm-personal-details\">\n\t\t\t\t\t\t\t<div class=\"awsm-content-scrollbar\">\n\t\t\t\t\t\t\t\t<span><\/span><h2>Dr. Liudmila Sosulina<\/h2>\n<p class=\"wp-block-paragraph\">coming soon<\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"awsm-personal-contact-info\">\n\t\t\t\t\t   <div class=\"awsm-contact-details\"><p><span>Institut:<\/span><a href=\"https:\/\/www.lin-magdeburg.de\/\" target=\"_blank\">Leibniz-Institut\u00a0f\u00fcr Neurobiologie (LIN)\u00a0Magdeburg<\/a><\/p><p><span>Projekt:<\/span><a href=\"https:\/\/sfb1436.de\/de\/projekte\/a03-theta-aktivitaet-dekodierung-inhibitorischer-schaltkreise-in-der-alzheimer-maus-mensch-forschung\/\" target=\"_blank\"><b>A03<\/b> Theta Aktivit\u00e4t: Dekodierung inhibitorischer Schaltkreise in der Alzheimer-Maus-Mensch-Forschung<\/a><\/p><\/div><div class=\"awsm-social-icons\"><span><a href=\"mailto:Liudmila.Sosulina@lin-magdeburg.de\"><i class=\"awsm-icon-mail\" aria-hidden=\"true\"><\/i><\/a><\/span><span><a href=\"https:\/\/www.lin-magdeburg.de\/forschung\/forschungseinheiten\/abteilung-zellulaere-neurowissenschaften\" target=\"_blank\"><i class=\"awsm-icon-link\" aria-hidden=\"true\"><\/i><\/a><\/span><\/div>\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t<\/div>\n\t<\/div>\n\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading alignwide has-text-align-center has-secondary-color has-text-color has-medium-font-size\" id=\"unsere-forschung\" style=\"font-style:normal;font-weight:500\">Unsere Forschung<\/h2>\n\n\n\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-f56f613f wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"wp-block-paragraph\">Hierf\u00fcr benutzen wir transgene Maus-Modelle, welche Alzheimer-spezifische Krankheitszeichen, wie etwa die Akkumulation von Amyloid-Beta Plaques im Gehirn aufweisen. Mittels Floureszenz-in-situ-Hybridisierung Zelltyp-spezifischer mRNA k\u00f6nnen wir die Pr\u00e4velenz und die Verteilung der verschieden Zellpopulationen in wildtyp und transgenen Tieren vergleichen. In-vivo Zweiphotonen-Mikroskipie erlaubt es uns die Aktivit\u00e4t hunderter hippocampaler Neuronen aufzunehmen w\u00e4hrend transgene und wildtyp Tiere eine r\u00e4umliche Ged\u00e4chtnisaufgabe erf\u00fcllen. Mit Hilfe auf maschinellem Lernen basierender Analyse-Techniken m\u00f6chten wir Korrelate zwischen ver\u00e4ndertem Verhalten und gest\u00f6rter hippocampaler Aktivit\u00e4t w\u00e4hrend der Ged\u00e4chtnisaufgabe finden.&nbsp; Desweiteren erforschen wir inwiefern transgene Tiere Gebrauch von kognitiven Ressourcen machen um die krankheitsbedingte St\u00f6rung spezifischer hippocampaler Schaltkreise zu kompensieren.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"wp-block-paragraph\">Es ist bekannt, dass Bewegung bei Nagetieren die Hirnaktivit\u00e4t ver\u00e4ndert. In einem translationalen Ansatz untersuchen wir, ob die motorische Aktivit\u00e4t das Potenzial hat, die Theta-Aktivit\u00e4t des Hirnstroms zu regulieren, um somit zu einer Verbesserung der Ged\u00e4chtnisleistung bei Menschen zu f\u00fchren. Die Vorstellung, dass Bewegung und Kognition eng miteinander verbunden sind, geht auf die erstaunlich moderne peripatetische Philosophieschule im alten Griechenland zur\u00fcck. Eine zentrale Annahme ist, dass Bewegung Ged\u00e4chtnis, Aufmerksamkeit und kreatives Denken f\u00f6rdern kann. Bisher gibt es nur wenige Verhaltensstudien mit Menschen, die zeigen, dass z.B. das Gehen mit einer Verbesserung kreativen Denkens einhergeht. Die neurophysiologischen Mechanismen auf der Ebene funktioneller neuronaler Netzwerke sind jedoch noch weitesgehend unklar. <\/p>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns alignfull has-white-color has-secondary-background-color has-text-color has-background is-layout-flex wp-container-core-columns-is-layout-cda6d148 wp-block-columns-is-layout-flex\" id=\"ziele\" style=\"margin-top:0px;margin-bottom:0px;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\">\n<h2 class=\"wp-block-heading has-text-align-right\" id=\"die-ziele-unseres-projektes\"><strong>Die Ziele unseres Projektes<\/strong><\/h2>\n<\/div>\n\n\n\n<div class=\"wp-block-column has-project-c-background-color has-background is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:50px;padding-right:150px;padding-bottom:50px;padding-left:150px\">\n<p class=\"wp-block-paragraph\">Ziel unserer Forschung ist es, zu untersuchen, ob und wie Bewegung unsere Ged\u00e4chtniskapazit\u00e4t beeinflussen kann und wie die Aktivit\u00e4t neuronaler Netzwerke die Interaktion zwischen Bewegung und Kognition erm\u00f6glicht. Mit Hilfe der sehr guten zeitlichen und spektralen Aufl\u00f6sung von nicht-invasiven magnetoenzephalographischen und invasiven elektrokortikographischen Aufzeichnungen streben wir an, die neuronalen Mechanismen zu beschreiben. <\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns alignfull gap-none is-layout-flex wp-container-core-columns-is-layout-cda6d148 wp-block-columns-is-layout-flex\" style=\"margin-top:0px;margin-bottom:0px;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<div class=\"wp-block-cover is-light is-repeated\" style=\"min-height:428px;aspect-ratio:unset;\"><div class=\"wp-block-cover__image-background wp-image-12591 is-repeated\" style=\"background-position:64% 61%;background-image:url(https:\/\/sfb1436.de\/wp-content\/uploads\/2022\/05\/senior-man-playing-puzzle.png)\"><\/div><span aria-hidden=\"true\" class=\"wp-block-cover__background has-background-dim-20 has-background-dim\"><\/span><div class=\"wp-block-cover__inner-container is-layout-flow wp-block-cover-is-layout-flow\">\n<p class=\"has-text-align-center has-large-font-size wp-block-paragraph\"><\/p>\n<\/div><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<div class=\"wp-block-cover is-light is-repeated\"><div class=\"wp-block-cover__image-background wp-image-1187 is-repeated\" style=\"background-position:50% 50%;background-image:url(https:\/\/sfb1436.de\/wp-content\/uploads\/2021\/11\/news-beitrag3.jpg)\"><\/div><span aria-hidden=\"true\" class=\"wp-block-cover__background has-background-dim-0 has-background-dim\"><\/span><div class=\"wp-block-cover__inner-container is-layout-flow wp-block-cover-is-layout-flow\">\n<p class=\"has-large-font-size wp-block-paragraph\"><\/p>\n<\/div><\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns alignfull is-layout-flex wp-container-core-columns-is-layout-dca53f0c wp-block-columns-is-layout-flex\" id=\"publications\" style=\"margin-top:0px;margin-bottom:0px\">\n<div class=\"wp-block-column has-project-c-background-color has-background is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:100%\">\n<section class=\"wp-block-group alignfull is-layout-flow wp-block-group-is-layout-flow\" style=\"padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<div class=\"wp-block-columns alignfull has-project-c-background-color has-background is-layout-flex wp-container-core-columns-is-layout-44579ee7 wp-block-columns-is-layout-flex\" style=\"margin-top:0px;margin-bottom:0px;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h2 class=\"wp-block-heading has-text-align-center has-white-color has-text-color\" id=\"publications-of-the-project-a03\"><strong>Publikationen des Projektes A03<\/strong><\/h2>\n\n\n\n\t\t\t<div class=\"wp-block-uagb-post-carousel uagb-post-grid project-slider uagb-post__image-position-top uagb-post__image-disabled uagb-block-c3be90bf     uagb-post__arrow-outside uagb-slick-carousel uagb-post__items uagb-post__columns-3 is-carousel uagb-post__columns-tablet-2 uagb-post__columns-mobile-1\" data-total=\"1\" style=\"\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t<article class=\"uagb-post__inner-wrap\">\t\t\t\t\t\t\t\t<h4 class=\"uagb-post__title uagb-post__text\">\n\t\t\t\t<a href=\"https:\/\/doi.org\/10.1101\/2024.08.27.609593\" target=\"_blank\" rel=\"bookmark noopener noreferrer\">Neuronale Heterogenit\u00e4t im medialen Septum und im diagonalen Band von Broca: Klassen und Kontinua<\/a>\n\t\t\t<\/h4>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t\t<time datetime=\"2024-11-19T13:55:14+01:00\" class=\"uagb-post__date\">\n\t\t\t\t<span class=\"dashicons-calendar dashicons\"><\/span>\t\t\t\t\t19.11.2024\t\t\t\t<\/time>\n\t\t\t\t\t\t\t<div class=\"uagb-post__text\">\n\t\t\t\t\t<span class='uagb-post__taxonomy'>\n\t\t\t\t\t\t<span class=\"dashicons-tag dashicons\"><\/span>\t\t\t\t\t\t<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a03-de\/\">A03<\/a>\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class='uagb-post__text uagb-post__excerpt'>\n\t\t\t\t\t<p>Felix&nbsp;Kuhn,&nbsp;Petra&nbsp;Mocellin,&nbsp;Stefano&nbsp;Pupe,&nbsp;Lihua&nbsp;Wang, Andrew L.&nbsp;Lemire,&nbsp;Liudmila&nbsp;Sosulina,&nbsp;Oliver&nbsp;Barnstedt,&nbsp;Nelson&nbsp;Spruston,&nbsp;Mark S.&nbsp;Cembrowski,&nbsp;Stefan&nbsp;Remy <span class=\"excerpt-magazin\">bioRxiv (2024)<\/span><\/p>\n<\/span>\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<article class=\"uagb-post__inner-wrap\">\t\t\t\t\t\t\t\t<h4 class=\"uagb-post__title uagb-post__text\">\n\t\t\t\t<a href=\"https:\/\/doi.org\/10.1101\/2024.07.10.602924\" target=\"_blank\" rel=\"bookmark noopener noreferrer\">Physical activity modulates early visual response and improves target detection in humans<\/a>\n\t\t\t<\/h4>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t\t<time datetime=\"2024-07-16T11:40:00+02:00\" class=\"uagb-post__date\">\n\t\t\t\t<span class=\"dashicons-calendar dashicons\"><\/span>\t\t\t\t\t16.07.2024\t\t\t\t<\/time>\n\t\t\t\t\t\t\t<div class=\"uagb-post__text\">\n\t\t\t\t\t<span class='uagb-post__taxonomy'>\n\t\t\t\t\t\t<span class=\"dashicons-tag dashicons\"><\/span>\t\t\t\t\t\t<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a03-de\/\">A03<\/a>\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class='uagb-post__text uagb-post__excerpt'>\n\t\t\t\t\t<p>Weischner, T., Che, X., Schmid, P., Reichert, C., Scholz, A., Knight, R.T., D\u00fcrschmid, S. bioRxiv (2024)<\/p>\n<\/span>\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<article class=\"uagb-post__inner-wrap\">\t\t\t\t\t\t\t\t<h4 class=\"uagb-post__title uagb-post__text\">\n\t\t\t\t<a href=\"https:\/\/doi.org\/10.1101\/2024.07.10.602896\" target=\"_blank\" rel=\"bookmark noopener noreferrer\">Physical Exercise Improves Working Memory through Ripple-Spindle Coupling<\/a>\n\t\t\t<\/h4>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t\t<time datetime=\"2024-07-15T10:58:00+02:00\" class=\"uagb-post__date\">\n\t\t\t\t<span class=\"dashicons-calendar dashicons\"><\/span>\t\t\t\t\t15.07.2024\t\t\t\t<\/time>\n\t\t\t\t\t\t\t<div class=\"uagb-post__text\">\n\t\t\t\t\t<span class='uagb-post__taxonomy'>\n\t\t\t\t\t\t<span class=\"dashicons-tag dashicons\"><\/span>\t\t\t\t\t\t<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a03-de\/\">A03<\/a>\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class='uagb-post__text uagb-post__excerpt'>\n\t\t\t\t\t<p>Che, X., Auer, B., Schmid, P., Reichert, C., Scholz, A., Weischner, T., Knight, R.T., D\u00fcrschmid, S. <span class=\"excerpt-magazin\">BioRxiv (2024)<\/span><\/p>\n<\/span>\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<article class=\"uagb-post__inner-wrap\">\t\t\t\t\t\t\t\t<h4 class=\"uagb-post__title uagb-post__text\">\n\t\t\t\t<a href=\"https:\/\/www.nature.com\/articles\/s41467-024-47361-x\" target=\"_blank\" rel=\"bookmark noopener noreferrer\">A hippocampus-accumbens code guides goal-directed appetitive behavior<\/a>\n\t\t\t<\/h4>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t\t<time datetime=\"2024-04-12T11:55:00+02:00\" class=\"uagb-post__date\">\n\t\t\t\t<span class=\"dashicons-calendar dashicons\"><\/span>\t\t\t\t\t12.04.2024\t\t\t\t<\/time>\n\t\t\t\t\t\t\t<div class=\"uagb-post__text\">\n\t\t\t\t\t<span class='uagb-post__taxonomy'>\n\t\t\t\t\t\t<span class=\"dashicons-tag dashicons\"><\/span>\t\t\t\t\t\t<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a03-de\/\">A03<\/a>\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class='uagb-post__text uagb-post__excerpt'>\n\t\t\t\t\t<p>Barnstedt O, Mocellin P, Remy S <span class=\"excerpt-magazin\">Nature Communications (2024)<\/span><\/p>\n<\/span>\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<article class=\"uagb-post__inner-wrap\">\t\t\t\t\t\t\t\t<h4 class=\"uagb-post__title uagb-post__text\">\n\t\t\t\t<a href=\"https:\/\/doi.org\/10.1016\/j.neuron.2023.12.016\" target=\"_blank\" rel=\"bookmark noopener noreferrer\">A septal to ventral tegmental area circuit drives exploratory behaviour<\/a>\n\t\t\t<\/h4>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t\t<time datetime=\"2024-02-02T10:27:58+01:00\" class=\"uagb-post__date\">\n\t\t\t\t<span class=\"dashicons-calendar dashicons\"><\/span>\t\t\t\t\t02.02.2024\t\t\t\t<\/time>\n\t\t\t\t\t\t\t<div class=\"uagb-post__text\">\n\t\t\t\t\t<span class='uagb-post__taxonomy'>\n\t\t\t\t\t\t<span class=\"dashicons-tag dashicons\"><\/span>\t\t\t\t\t\t<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a02-de\/\">A02<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a03-de\/\">A03<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a04-de\/\">A04<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/b06-de\/\">B06<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/z01-de\/\">Z01<\/a>\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class='uagb-post__text uagb-post__excerpt'>\n\t\t\t\t\t<p>Mocellin P, Barnstedt O,Luxem K, Kaneko H, Karpova A, Henschke J, Dal\u00fcgge D, Fuhrmann F, Pakan JMP, Kreutz MR, MikulovicS, and Remy S <span class=\"excerpt-magazin\">Neuron (2024)<\/span><\/p>\n<\/span>\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<article class=\"uagb-post__inner-wrap\">\t\t\t\t\t\t\t\t<h4 class=\"uagb-post__title uagb-post__text\">\n\t\t\t\t<a href=\"https:\/\/doi.org\/10.1109\/CBMS58004.2023.00225\" target=\"_blank\" rel=\"bookmark noopener noreferrer\">Inferring Salient Motifs during Learning Experiments<\/a>\n\t\t\t<\/h4>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t\t<time datetime=\"2023-06-26T09:11:25+02:00\" class=\"uagb-post__date\">\n\t\t\t\t<span class=\"dashicons-calendar dashicons\"><\/span>\t\t\t\t\t26.06.2023\t\t\t\t<\/time>\n\t\t\t\t\t\t\t<div class=\"uagb-post__text\">\n\t\t\t\t\t<span class='uagb-post__taxonomy'>\n\t\t\t\t\t\t<span class=\"dashicons-tag dashicons\"><\/span>\t\t\t\t\t\t<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a03-de\/\">A03<\/a>\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class='uagb-post__text uagb-post__excerpt'>\n\t\t\t\t\t<p>Jamaludeen N, Kuhn F, Brechmann A, Fuhrmann F, Remy S and Spiliopoulou M <span class=\"excerpt-magazin\">IEEE Symposium on Computer-Based Medical Systems (2023)<\/span><\/p>\n<\/span>\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<article class=\"uagb-post__inner-wrap\">\t\t\t\t\t\t\t\t<h4 class=\"uagb-post__title uagb-post__text\">\n\t\t\t\t<a href=\"https:\/\/doi.org\/10.1113\/jp283401\" target=\"_blank\" rel=\"bookmark noopener noreferrer\">Modelling the contributions to hyperexcitability in a mouse model of Alzheimer&#8217;s disease<\/a>\n\t\t\t<\/h4>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t\t<time datetime=\"2023-02-03T08:50:44+01:00\" class=\"uagb-post__date\">\n\t\t\t\t<span class=\"dashicons-calendar dashicons\"><\/span>\t\t\t\t\t03.02.2023\t\t\t\t<\/time>\n\t\t\t\t\t\t\t<div class=\"uagb-post__text\">\n\t\t\t\t\t<span class='uagb-post__taxonomy'>\n\t\t\t\t\t\t<span class=\"dashicons-tag dashicons\"><\/span>\t\t\t\t\t\t<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a03-de\/\">A03<\/a>\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class='uagb-post__text uagb-post__excerpt'>\n\t\t\t\t\t<p>Mittag M, Mediavilla L, Remy S, Cuntz H, Jedlicka P <span class=\"excerpt-magazin\">Journal of Physiology (2023)<\/span><\/p>\n<\/span>\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<article class=\"uagb-post__inner-wrap\">\t\t\t\t\t\t\t\t<h4 class=\"uagb-post__title uagb-post__text\">\n\t\t\t\t<a href=\"https:\/\/doi.org\/10.15252\/embj.2022112453\" target=\"_blank\" rel=\"bookmark noopener noreferrer\">Jacob-induced transcriptional inactivation of CREB promotes A\u03b2-induced synapse loss in Alzheimer&#8217;s disease<\/a>\n\t\t\t<\/h4>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t\t<time datetime=\"2023-01-03T17:15:59+01:00\" class=\"uagb-post__date\">\n\t\t\t\t<span class=\"dashicons-calendar dashicons\"><\/span>\t\t\t\t\t03.01.2023\t\t\t\t<\/time>\n\t\t\t\t\t\t\t<div class=\"uagb-post__text\">\n\t\t\t\t\t<span class='uagb-post__taxonomy'>\n\t\t\t\t\t\t<span class=\"dashicons-tag dashicons\"><\/span>\t\t\t\t\t\t<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a02-de\/\">A02<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a03-de\/\">A03<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a04-de\/\">A04<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/z01-de\/\">Z01<\/a>\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class='uagb-post__text uagb-post__excerpt'>\n\t\t\t\t\t<p>K. M Grochowska, G. M Gomes, R. Raman, R. Kaushik, L. Sosulina, H. Kaneko, A. M Oelschlegel, P. Yuanxiang, I. Reyes-Resina, G. Bayraktar, S. Samer, C. Spilker, M. S Woo, M. Morawski, J. Goldschmidt,&nbsp;M. A Friese, S. Rossner,&nbsp;G. Navarro, S&#8230;.<\/span>\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<article class=\"uagb-post__inner-wrap\">\t\t\t\t\t\t\t\t<h4 class=\"uagb-post__title uagb-post__text\">\n\t\t\t\t<a href=\"https:\/\/doi.org\/10.1038\/s42003-022-04080-7\" target=\"_blank\" rel=\"bookmark noopener noreferrer\">Identifying behavioral structure from deep variational embeddings of animal motion<\/a>\n\t\t\t<\/h4>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t\t<time datetime=\"2022-11-18T10:08:32+01:00\" class=\"uagb-post__date\">\n\t\t\t\t<span class=\"dashicons-calendar dashicons\"><\/span>\t\t\t\t\t18.11.2022\t\t\t\t<\/time>\n\t\t\t\t\t\t\t<div class=\"uagb-post__text\">\n\t\t\t\t\t<span class='uagb-post__taxonomy'>\n\t\t\t\t\t\t<span class=\"dashicons-tag dashicons\"><\/span>\t\t\t\t\t\t<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a03-de\/\">A03<\/a>\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class='uagb-post__text uagb-post__excerpt'>\n\t\t\t\t\t<p>Luxem K, Mocellin P, Fuhrmann F, K\u00fcrsch J, Miller SR, Palop JJ, Remy S, Bauer P. <span class=\"excerpt-magazin\">Communications Biology (2022)<\/span><\/p>\n<\/span>\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<article class=\"uagb-post__inner-wrap\">\t\t\t\t\t\t\t\t<h4 class=\"uagb-post__title uagb-post__text\">\n\t\t\t\t<a href=\"https:\/\/doi.org\/10.1109\/COMPENG50184.2022.9905445\" target=\"_blank\" rel=\"bookmark noopener noreferrer\">Visual spatial attention shifts decoded from the electroencephalogram enable sending of binary messages.<\/a>\n\t\t\t<\/h4>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t\t<time datetime=\"2022-10-06T10:18:05+02:00\" class=\"uagb-post__date\">\n\t\t\t\t<span class=\"dashicons-calendar dashicons\"><\/span>\t\t\t\t\t06.10.2022\t\t\t\t<\/time>\n\t\t\t\t\t\t\t<div class=\"uagb-post__text\">\n\t\t\t\t\t<span class='uagb-post__taxonomy'>\n\t\t\t\t\t\t<span class=\"dashicons-tag dashicons\"><\/span>\t\t\t\t\t\t<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a03-de\/\">A03<\/a>\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class='uagb-post__text uagb-post__excerpt'>\n\t\t\t\t\t<p>Reichert C, D\u00fcrschmid S, Sweeney-Reed CM, Hinrichs H <span class=\"excerpt-magazin\">IEEE Workshop on Complexity in Engineering (2022)<\/span><\/p>\n<\/span>\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<article class=\"uagb-post__inner-wrap\">\t\t\t\t\t\t\t\t<h4 class=\"uagb-post__title uagb-post__text\">\n\t\t\t\t<a href=\"https:\/\/doi.org\/10.1038\/s42003-022-03861-4\" target=\"_blank\" rel=\"bookmark noopener noreferrer\">Distinct interacting cortical networks for stimulus-response and repetition-suppression<\/a>\n\t\t\t<\/h4>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t\t<time datetime=\"2022-09-05T09:18:25+02:00\" class=\"uagb-post__date\">\n\t\t\t\t<span class=\"dashicons-calendar dashicons\"><\/span>\t\t\t\t\t05.09.2022\t\t\t\t<\/time>\n\t\t\t\t\t\t\t<div class=\"uagb-post__text\">\n\t\t\t\t\t<span class='uagb-post__taxonomy'>\n\t\t\t\t\t\t<span class=\"dashicons-tag dashicons\"><\/span>\t\t\t\t\t\t<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a03-de\/\">A03<\/a>\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class='uagb-post__text uagb-post__excerpt'>\n\t\t\t\t\t<p>Eckert D, Reichert C, Bien CG, Heinze H-J, Knight RT, Deouell LY, D\u00fcrschmid S <span class=\"excerpt-magazin\">Communications Biology (2022)<\/span><\/p>\n<\/span>\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<article class=\"uagb-post__inner-wrap\">\t\t\t\t\t\t\t\t<h4 class=\"uagb-post__title uagb-post__text\">\n\t\t\t\t<a href=\"https:\/\/doi.org\/10.1109\/COMPENG50184.2022.9905448\" target=\"_blank\" rel=\"bookmark noopener noreferrer\">Functional electrical stimulation driven by a brain\u2013computer interface in acute and subacute stroke patients impacts beta power and long-range temporal correlation<\/a>\n\t\t\t<\/h4>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t\t<time datetime=\"2022-07-23T09:57:21+02:00\" class=\"uagb-post__date\">\n\t\t\t\t<span class=\"dashicons-calendar dashicons\"><\/span>\t\t\t\t\t23.07.2022\t\t\t\t<\/time>\n\t\t\t\t\t\t\t<div class=\"uagb-post__text\">\n\t\t\t\t\t<span class='uagb-post__taxonomy'>\n\t\t\t\t\t\t<span class=\"dashicons-tag dashicons\"><\/span>\t\t\t\t\t\t<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a03-de\/\">A03<\/a>\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class='uagb-post__text uagb-post__excerpt'>\n\t\t\t\t\t<p>Krueger J, Krauth R, Reichert C, Perdikis S, Vogt S, Huchtemann T, D\u00fcrschmid S, Sickert A, Lamprecht J, Huremovic A, Goertler M, Nasuto SJ, Knight RT, Hinrichs H, Heinze H-J, Lindquist S, Sailer M, Mill\u00e1n JDR, Sweeney-Reed, CM IEEE Workshop&#8230;<\/span>\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-19fccbcd wp-block-buttons-is-layout-flex\" style=\"margin-top:40px;margin-bottom:0px\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link has-project-c-color has-white-background-color has-text-color has-background wp-element-button\" href=\"https:\/\/sfb1436.de\/de\/publikationen\/\">Alle Publikationen<\/a><\/div>\n\n\n\n<div class=\"wp-block-button is-style-outline is-style-outline--1\"><a class=\"wp-block-button__link has-white-color has-text-color wp-element-button\" href=\"https:\/\/sfb1436.de\/de\/projekte\/\">Alle Projekte<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Unser Maus-Mensch-Projekt untersucht, wie Beeintr\u00e4chtigungen in inhibitorischen Mikroschaltkreisen w\u00e4hrend Theta-Phasen die Verarbeitung von Umgebungsinformationen, besonders in Alzheimer-Modellen, beeinflussen. Wir konzentrieren uns auf verschiedene inhibitorische Schaltkreise und ihre Auswirkungen auf kognitive Funktionen wie Ged\u00e4chtnisencodierung und -abruf. Durch den Einsatz von hAPP-Mausmodellen erforschen wir, wie Beta-Amyloidose diese Schaltkreise st\u00f6rt und zu Ged\u00e4chtnisdefiziten beitr\u00e4gt. An MCI Patienten zeigen [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":3279,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_crdt_document":"","_uag_custom_page_level_css":"","footnotes":""},"class_list":["post-6971","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Theta Aktivit\u00e4t- SFB1436<\/title>\n<meta name=\"description\" content=\"Unser Maus-Mensch-Projekt untersucht, wie Beeintr\u00e4chtigungen in inhibitorischen Mikroschaltkreisen w\u00e4hrend Theta-Phasen...\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sfb1436.de\/de\/projekte\/a03-theta-aktivitaet-dekodierung-inhibitorischer-schaltkreise-in-der-alzheimer-maus-mensch-forschung\/\" \/>\n<meta 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Beeintr\u00e4chtigungen in inhibitorischen Mikroschaltkreisen w\u00e4hrend Theta-Phasen die Verarbeitung von Umgebungsinformationen, besonders in Alzheimer-Modellen, beeinflussen. Wir konzentrieren uns auf verschiedene inhibitorische Schaltkreise und ihre Auswirkungen auf kognitive Funktionen wie Ged\u00e4chtnisencodierung und -abruf. Durch den Einsatz von hAPP-Mausmodellen erforschen wir, wie Beta-Amyloidose diese Schaltkreise st\u00f6rt und zu Ged\u00e4chtnisdefiziten beitr\u00e4gt. An MCI Patienten zeigen&hellip;","_links":{"self":[{"href":"https:\/\/sfb1436.de\/de\/wp-json\/wp\/v2\/pages\/6971","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sfb1436.de\/de\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sfb1436.de\/de\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sfb1436.de\/de\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/sfb1436.de\/de\/wp-json\/wp\/v2\/comments?post=6971"}],"version-history":[{"count":53,"href":"https:\/\/sfb1436.de\/de\/wp-json\/wp\/v2\/pages\/6971\/revisions"}],"predecessor-version":[{"id":27435,"href":"https:\/\/sfb1436.de\/de\/wp-json\/wp\/v2\/pages\/6971\/revisions\/27435"}],"up":[{"embeddable":true,"href":"https:\/\/sfb1436.de\/de\/wp-json\/wp\/v2\/pages\/3279"}],"wp:attachment":[{"href":"https:\/\/sfb1436.de\/de\/wp-json\/wp\/v2\/media?parent=6971"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}