{"id":6965,"date":"2022-03-28T14:02:09","date_gmt":"2022-03-28T12:02:09","guid":{"rendered":"https:\/\/sfb1436.de\/menue-1\/shaping-neuronal-engram-ensembles-through-excitation-transcription-coupling\/"},"modified":"2025-05-19T06:29:45","modified_gmt":"2025-05-19T04:29:45","slug":"a02_die-bildung-von-gedaechtnisspuren-ueber-exzitations-transkriptionskopplung","status":"publish","type":"page","link":"https:\/\/sfb1436.de\/de\/projekte\/a02_die-bildung-von-gedaechtnisspuren-ueber-exzitations-transkriptionskopplung\/","title":{"rendered":"A02 &#8211; Die Bildung von Ged\u00e4chtnisspuren \u00fcber Exzitations-Transkriptionskopplung"},"content":{"rendered":"\n<div class=\"wp-block-uagb-section uagb-section__wrap uagb-section__background-color uagb-block-877fd984 badge-title\"><div class=\"uagb-section__overlay\"><\/div><div class=\"uagb-section__inner-wrap\">\n<p class=\"has-text-align-center wp-block-paragraph\">A02<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group alignwide has-white-background-color has-background is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-columns are-vertically-aligned-center is-layout-flex wp-container-core-columns-is-layout-147ade55 wp-block-columns-is-layout-flex\" style=\"padding-top:0px;padding-bottom:0px\">\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:20px;padding-right:20px;padding-bottom:20px;padding-left:20px\">\n<figure class=\"wp-block-image aligncenter size-full\"><a href=\"https:\/\/sfb1436.de\/wp-content\/uploads\/2025\/01\/A02_25-28_abstract.png\"><img fetchpriority=\"high\" decoding=\"async\" width=\"932\" height=\"455\" src=\"https:\/\/sfb1436.de\/wp-content\/uploads\/2025\/01\/A02_25-28_abstract.png\" alt=\"graphical abstract of A02\" class=\"wp-image-25024\"\/><\/a><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-left wp-block-paragraph\">Expression von Genen unterst\u00fctzt, die die Bildung von Ged\u00e4chtnisspuren f\u00f6rdern. Wir wollen uns Mechanismen von Exzitations-Transkriptionskopplung als neuronale Ressource zunutze machen, um die Ged\u00e4chtnisbildung zu f\u00f6rdern. Wir konnten bereits zeigen, dass Interventionen, die diesen Signalweg ver\u00e4ndern, die kognitive Leistungsf\u00e4higkeit verbessern. \u00dcbergeordnetes Ziel des Projekts ist aufbauend auf den entschl\u00fcsselten Mechanismen dem kognitiven Abbau im Alter und bei der Alzheimer Demenz entgegenzuwirken.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns are-vertically-aligned-top is-layout-flex wp-container-core-columns-is-layout-43c3a9c5 wp-block-columns-is-layout-flex\" id=\"project-anchor\" style=\"padding-top:0px;padding-bottom:30px\">\n<div class=\"wp-block-column is-vertically-aligned-top is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-f56f613f wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" id=\"projekt\">\n<div class=\"wp-block-buttons is-horizontal is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-b0be8b0e wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button has-custom-width wp-block-button__width-100 is-style-fill\"><a class=\"wp-block-button__link has-white-color has-project-c-background-color has-text-color has-background has-normal-font-size has-custom-font-size wp-element-button\" href=\"#project-a02\"><strong>Unsere Forschung<\/strong><\/a><\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-buttons is-horizontal is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-b0be8b0e wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button has-custom-width wp-block-button__width-100 is-style-fill\"><a class=\"wp-block-button__link has-white-color has-secondary-background-color has-text-color has-background has-normal-font-size has-custom-font-size wp-element-button\" href=\"#the-goals-of-our-project\"><strong>Ziele unseres Projektes <\/strong><\/a><\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-buttons is-horizontal is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-b0be8b0e wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button has-custom-width wp-block-button__width-100 is-style-fill\"><a class=\"wp-block-button__link has-white-color has-project-c-background-color has-text-color has-background has-normal-font-size has-custom-font-size wp-element-button\" href=\"#publications\"><strong>Publikationen<\/strong><\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns alignfull has-tertiary-background-color has-background is-layout-flex wp-container-core-columns-is-layout-763026b3 wp-block-columns-is-layout-flex\" style=\"margin-top:0px;margin-bottom:0px\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" id=\"pi\">\n<h2 class=\"wp-block-heading has-text-align-center\" id=\"gruppenleitung\" style=\"font-style:normal;font-weight:500\">Gruppenleitung<\/h2>\n\n\n<div id=\"awsm-team-25025\" class=\"awsm-grid-wrapper\">\n\t\t\n\t\t<div class=''>\n\t\t<div class=\"gridder awsm-grid drawer-style style-1 grid-2-col \">\n\t\t\t\t\t\t<div id=\"awsm-member-25025-3673\" class=\"awsm-grid-list awsm-grid-card awsm-team-item awsm-scale-anm awsm-all awsm-100\" data-griddercontent=\"#awsm-grid-content-3673\">\n\t\t\t\t\t<span class=\"awsm-team-link-control awsm-grid-list-item awsm-grid-list-item-3673\" data-info=\"3673\">\n\t\t\t\t\t\t<figure>\n\t\t\t\t\t\t<img decoding=\"async\" width=\"800\" height=\"1000\" src=\"https:\/\/sfb1436.de\/wp-content\/uploads\/2025\/05\/Anna-Karpova-800x1000.jpg\" class=\"attachment-awsm_team size-awsm_team wp-post-image\" alt=\"SFB 1436 Mitglied Anna Karpova\" \/>\t\t\t\t\t\t\t<figcaption>\n\t\t\t\t\t\t\t\t<div class=\"awsm-personal-info\"><span><\/span><h3>Dr. Anna Karpova<\/h3><\/div>\t\t\t\t\t\t\t<\/figcaption>\n\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div id=\"awsm-member-25025-3680\" class=\"awsm-grid-list awsm-grid-card awsm-team-item awsm-scale-anm awsm-all\" data-griddercontent=\"#awsm-grid-content-3680\">\n\t\t\t\t\t<span class=\"awsm-team-link-control awsm-grid-list-item awsm-grid-list-item-3680\" data-info=\"3680\">\n\t\t\t\t\t\t<figure>\n\t\t\t\t\t\t<img decoding=\"async\" width=\"800\" height=\"533\" src=\"https:\/\/sfb1436.de\/wp-content\/uploads\/2021\/12\/michael-kreutz-scaled.jpg\" class=\"attachment-awsm_team size-awsm_team wp-post-image\" alt=\"SFB 1436 Mitglied Michael Kreutz\" \/>\t\t\t\t\t\t\t<figcaption>\n\t\t\t\t\t\t\t\t<div class=\"awsm-personal-info\"><span><\/span><h3>Prof. Dr. Michael R. Kreutz<\/h3><\/div>\t\t\t\t\t\t\t<\/figcaption>\n\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div id=\"awsm-member-25025-14152\" class=\"awsm-grid-list awsm-grid-card awsm-team-item awsm-scale-anm awsm-all\" data-griddercontent=\"#awsm-grid-content-14152\">\n\t\t\t\t\t<span class=\"awsm-team-link-control awsm-grid-list-item awsm-grid-list-item-14152\" data-info=\"14152\">\n\t\t\t\t\t\t<figure>\n\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"1000\" src=\"https:\/\/sfb1436.de\/wp-content\/uploads\/2025\/05\/Katarzyna-Grochowska-800x1000.jpg\" class=\"attachment-awsm_team size-awsm_team wp-post-image\" alt=\"SFB 1436 Mitglied Katarzyna Grochowska\" \/>\t\t\t\t\t\t\t<figcaption>\n\t\t\t\t\t\t\t\t<div class=\"awsm-personal-info\"><span><\/span><h3>Dr. Katarzyna Grochowska<\/h3><\/div>\t\t\t\t\t\t\t<\/figcaption>\n\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<div class=\"awsm-grid-expander style-1\">\n\t\t\t\t\t\t<div id=\"awsm-member-info-25025-3673\"  class=\"awsm-grid-expander style-1\">\n\t\t\t\t<div class=\"awsm-detailed-info\" id=\"awsm-grid-content-3673\">\n\t\t\t\t\t<div class=\"awsm-details\">\n\t\t\t\t\t\t<div class=\"awsm-personal-details\">\n\t\t\t\t\t\t\t<div class=\"awsm-content-scrollbar\">\n\t\t\t\t\t\t\t\t<span><\/span><h2>Dr. Anna Karpova<\/h2>\n<p class=\"wp-block-paragraph\">Anna Karpova ist wissenschaftliche F\u00fchrungskraft (PI) in der Forschungsgruppe &#8222;Neuroplasticity&#8220; und leitet das Projekt zusammen mit Michael Kreutz am Leibniz Institut f\u00fcr Neurobiolgie. Sie ist ferner PI im Magdeburger Center for Behavorial Brain Sciences <u>(<a rel=\"noreferrer noopener\" href=\"http:\/\/www.cbbs.eu\" target=\"_blank\">CBBS<\/a>)<\/u> und Koordinatorin der Sektion Molekular &amp; Zellbiologie am LIN. Ihre Expertise in molekularer und zellul\u00e4rer Neurobiologie nutzt sie zur Charakterisierung der strukturellen und funktionellen Organisation chemischer, plastischer Synapsen. Sie untersucht den intrazellul\u00e4ren Protein- und Membrantransport \u00fcber l\u00e4ngere Distanzen und dessen Rolle f\u00fcr neuronale Funktionen. Daf\u00fcr nutzt sie u.a mikroskopische Time-lapse und Super-Resolution Verfahren.<\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"awsm-personal-contact-info\">\n\t\t\t\t\t   <div class=\"awsm-contact-details\"><p><span>Institut:<\/span><a href=\"https:\/\/www.lin-magdeburg.de\/\" target=\"_blank\">Leibniz-Institut\u00a0f\u00fcr Neurobiologie (LIN)\u00a0Magdeburg<\/a><\/p><p><span>Project Title:<\/span><a href=\"\/de\/projekte\/a02_die-bildung-von-gedaechtnisspuren-ueber-exzitations-transkriptionskopplung\/\" target=\"_blank\"><b>A02<\/b> Die Bildung von Ged\u00e4chtnisspuren \u00fcber Exzitations-Transkriptionskopplung<\/a><\/p><\/div><div class=\"awsm-social-icons\"><span><a href=\"mailto:akarpova@lin-magdeburg.de\"><i class=\"awsm-icon-mail\" aria-hidden=\"true\"><\/i><\/a><\/span><span><a href=\"tel:+49-391-6263-94371\" target=\"_blank\"><i class=\"awsm-icon-phone\" aria-hidden=\"true\"><\/i><\/a><\/span><span><a href=\"https:\/\/www.lin-magdeburg.de\/forschung\/forschergruppe-neuroplastizitaet\" target=\"_blank\"><i class=\"awsm-icon-link\" aria-hidden=\"true\"><\/i><\/a><\/span><\/div>\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<div id=\"awsm-member-info-25025-3680\"  class=\"awsm-grid-expander style-1\">\n\t\t\t\t<div class=\"awsm-detailed-info\" id=\"awsm-grid-content-3680\">\n\t\t\t\t\t<div class=\"awsm-details\">\n\t\t\t\t\t\t<div class=\"awsm-personal-details\">\n\t\t\t\t\t\t\t<div class=\"awsm-content-scrollbar\">\n\t\t\t\t\t\t\t\t<span><\/span><h2>Prof. Dr. Michael R. Kreutz<\/h2>\n<p class=\"wp-block-paragraph\">Michael R. Kreutz leitet die Forschungsgruppe &#8222;Neuroplasticity&#8220; am Leibniz Institut f\u00fcr Neurobiologie sowie die Leibniz Gruppe &#8222;Dendritic Organelles and Synaptic Function&#8220; am Zentrum f\u00fcr Molekulare Zellbiologie in Hamburg (ZMNH). Sein Forschungsschwerpunkt liegt auf der Biologie der Synapse, inbsesondere befasst er sich mit grundlegenden Fragen zur Kommunikation zwischen Synapse und Zellkern. Dies schlie\u00dft die Frage nach R\u00fcckkopplung zwischen Aktivit\u00e4ts-abh\u00e4ngiger Genexpression und synaptischer Funktion sowie deren Auswirkung auf die Bildung zellul\u00e4rer Engramme ein. Nicht zuletzt untersucht er, wie die Nano-Organisation von Synapsen deren funktionelle Eigenschaften im Kontext von Lernen und Ged\u00e4chtnis bestimmt.&nbsp;<\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"awsm-personal-contact-info\">\n\t\t\t\t\t   <div class=\"awsm-contact-details\"><p><span>Institut:<\/span><a href=\"https:\/\/www.lin-magdeburg.de\/\" target=\"_blank\">Leibniz-Institut\u00a0f\u00fcr Neurobiologie (LIN)\u00a0Magdeburg<\/a><\/p><p><span>Project Title:<\/span><a href=\"\/de\/projekte\/a02_die-bildung-von-gedaechtnisspuren-ueber-exzitations-transkriptionskopplung\/\" target=\"_blank\"><b>A02<\/b> Die Bildung von Ged\u00e4chtnisspuren \u00fcber Exzitations-Transkriptionskopplung<\/a><\/p><p><span>:<\/span><a href=\"https:\/\/sfb1436.de\/de\/projekte\/a04_verbesserung-der-kognitiven-leistungsfaehigkeit-durch-das-anti-aging-hormon-klotho\/\" target=\"_blank\"><b>A04<\/b> Verbesserung der kognitiven Leistungsf\u00e4higkeit durch das Anti-Aging Hormon Klotho \u2013 Von molekularen Mechanismen zu Interventionen<\/a><\/p><p><span>Project Title:<\/span><a href=\"https:\/\/sfb1436.de\/de\/projekte\/z01-funktionelle-analyse-von-neuronalen-netzwerken-in-nagern\/\" target=\"_blank\"><b>Z01<\/b> Funktionelle Analyse von neuronalen Netzwerken in Nagern<\/a><\/p><\/div><div class=\"awsm-social-icons\"><span><a href=\"mailto:Michael.Kreutz@lin-magdeburg.de\"><i class=\"awsm-icon-mail\" aria-hidden=\"true\"><\/i><\/a><\/span><span><a href=\"tel:+49-391-6263-94171\" target=\"_blank\"><i class=\"awsm-icon-phone\" aria-hidden=\"true\"><\/i><\/a><\/span><span><a href=\"http:\/\/www.kreutzlab.com\/\" target=\"_blank\"><i class=\"awsm-icon-link\" aria-hidden=\"true\"><\/i><\/a><\/span><\/div>\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<div id=\"awsm-member-info-25025-14152\"  class=\"awsm-grid-expander style-1\">\n\t\t\t\t<div class=\"awsm-detailed-info\" id=\"awsm-grid-content-14152\">\n\t\t\t\t\t<div class=\"awsm-details\">\n\t\t\t\t\t\t<div class=\"awsm-personal-details\">\n\t\t\t\t\t\t\t<div class=\"awsm-content-scrollbar\">\n\t\t\t\t\t\t\t\t<span><\/span><h2>Dr. Katarzyna Grochowska<\/h2>\n<p class=\"wp-block-paragraph\">Katarzyna M. Grochowska erwarb ihren M.Sc. in Biotechnologie an der Warschauer Universit\u00e4t f\u00fcr Biowissenschaften, Warschau, Polen. Anschlie\u00dfend promovierte sie am Leibniz-Institut f\u00fcr Neurobiologie (LIN) im Rahmen eines Marie Sklodowska-Curie ITN-Programms unter der Leitung von Dr. Michael Kreutz. W\u00e4hrend ihrer Doktorarbeit besch\u00e4ftigte sie sich mit den molekularen Mechanismen neurodegenerativer Erkrankungen, insbesondere der Alzheimer-Krankheit. Derzeit untersucht sie die Mechanismen der Neurodegeneration, insbesondere im Zusammenhang mit der Kopplung von Erregung und Transkription, dem endolysosomalen Abbauweg und der neuroinflammatorischen Signal\u00fcbertragung.<\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"awsm-personal-contact-info\">\n\t\t\t\t\t   <div class=\"awsm-contact-details\"><p><span>Institut:<\/span><a href=\"https:\/\/www.lin-magdeburg.de\/\" target=\"_blank\">Leibniz Institut f\u00fcr Neurobiologie (LIN) Magdeburg<\/a><\/p><p><span>Projekt:<\/span><a href=\"\/de\/projekte\/a02_die-bildung-von-gedaechtnisspuren-ueber-exzitations-transkriptionskopplung\/\" target=\"_blank\"><b>A02<\/b> Die Bildung von Ged\u00e4chtnisspuren \u00fcber Exzitations-Transkriptionskopplung<\/a><\/p><\/div><div class=\"awsm-social-icons\"><span><a href=\"mailto:Katarzyna.Grochowska@lin-magdeburg.de\"><i class=\"awsm-icon-mail\" aria-hidden=\"true\"><\/i><\/a><\/span><span><a href=\"https:\/\/www.lin-magdeburg.de\/forschung\/forschergruppe-neuroplastizitaet\" target=\"_blank\"><i class=\"awsm-icon-link\" aria-hidden=\"true\"><\/i><\/a><\/span><\/div>\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t<\/div>\n\t<\/div>\n\n\n\n\n<div class=\"wp-block-columns justify-content-center is-layout-flex wp-container-core-columns-is-layout-f56f613f wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:1350px\">\n<h2 class=\"wp-block-heading has-text-align-center\" id=\"gruppenmitglieder\" style=\"font-style:normal;font-weight:500\">Gruppenmitglieder<\/h2>\n\n\n<div id=\"awsm-team-25026\" class=\"awsm-grid-wrapper\">\n\t\t\n\t\t<div class=''>\n\t\t<div class=\"gridder awsm-grid drawer-style style-1 grid-2-col \">\n\t\t\t\t\t\t<div id=\"awsm-member-25026-29426\" class=\"awsm-grid-list awsm-grid-card awsm-team-item awsm-scale-anm awsm-all awsm-114 awsm-117\" data-griddercontent=\"#awsm-grid-content-29426\">\n\t\t\t\t\t<span class=\"awsm-team-link-control awsm-grid-list-item awsm-grid-list-item-29426\" data-info=\"29426\">\n\t\t\t\t\t\t<figure>\n\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"1000\" src=\"https:\/\/sfb1436.de\/wp-content\/uploads\/2025\/11\/Patrick_Kraus-800x1000.webp\" class=\"attachment-awsm_team size-awsm_team wp-post-image\" alt=\"SFB 1436 Mitglied Patrick Kraus\" \/>\t\t\t\t\t\t\t<figcaption>\n\t\t\t\t\t\t\t\t<div class=\"awsm-personal-info\"><span><\/span><h3>Patrick Kraus<\/h3><\/div>\t\t\t\t\t\t\t<\/figcaption>\n\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div id=\"awsm-member-25026-3711\" class=\"awsm-grid-list awsm-grid-card awsm-team-item awsm-scale-anm awsm-all\" data-griddercontent=\"#awsm-grid-content-3711\">\n\t\t\t\t\t<span class=\"awsm-team-link-control awsm-grid-list-item awsm-grid-list-item-3711\" data-info=\"3711\">\n\t\t\t\t\t\t<figure>\n\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"1000\" src=\"https:\/\/sfb1436.de\/wp-content\/uploads\/2022\/05\/20210526-210-Anja-Oelschlegel-800x1000.jpg\" class=\"attachment-awsm_team size-awsm_team wp-post-image\" alt=\"SFB 1436 Mitglied Anja Oelschlegel\" \/>\t\t\t\t\t\t\t<figcaption>\n\t\t\t\t\t\t\t\t<div class=\"awsm-personal-info\"><span><\/span><h3>Dr. Anja Oelschlegel<\/h3><\/div>\t\t\t\t\t\t\t<\/figcaption>\n\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div id=\"awsm-member-25026-3719\" class=\"awsm-grid-list awsm-grid-card awsm-team-item awsm-scale-anm awsm-all\" data-griddercontent=\"#awsm-grid-content-3719\">\n\t\t\t\t\t<span class=\"awsm-team-link-control awsm-grid-list-item awsm-grid-list-item-3719\" data-info=\"3719\">\n\t\t\t\t\t\t<figure>\n\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"1000\" src=\"https:\/\/sfb1436.de\/wp-content\/uploads\/2022\/05\/Rajeev-Raman-800x1000.jpg\" class=\"attachment-awsm_team size-awsm_team wp-post-image\" alt=\"SFB 1436 Mitglied Rajeev Raman\" \/>\t\t\t\t\t\t\t<figcaption>\n\t\t\t\t\t\t\t\t<div class=\"awsm-personal-info\"><span><\/span><h3>Dr. Rajeev Raman<\/h3><\/div>\t\t\t\t\t\t\t<\/figcaption>\n\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div id=\"awsm-member-25026-3726\" class=\"awsm-grid-list awsm-grid-card awsm-team-item awsm-scale-anm awsm-all awsm-114 awsm-117\" data-griddercontent=\"#awsm-grid-content-3726\">\n\t\t\t\t\t<span class=\"awsm-team-link-control awsm-grid-list-item awsm-grid-list-item-3726\" data-info=\"3726\">\n\t\t\t\t\t\t<figure>\n\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"1000\" src=\"https:\/\/sfb1436.de\/wp-content\/uploads\/2022\/05\/20210615-Samer-611-800x1000.jpg\" class=\"attachment-awsm_team size-awsm_team wp-post-image\" alt=\"SFB 1436 Mitglied Sebastian Samer\" \/>\t\t\t\t\t\t\t<figcaption>\n\t\t\t\t\t\t\t\t<div class=\"awsm-personal-info\"><span><\/span><h3>Sebastian Samer<\/h3><\/div>\t\t\t\t\t\t\t<\/figcaption>\n\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div id=\"awsm-member-25026-3631\" class=\"awsm-grid-list awsm-grid-card awsm-team-item awsm-scale-anm awsm-all awsm-114\" data-griddercontent=\"#awsm-grid-content-3631\">\n\t\t\t\t\t<span class=\"awsm-team-link-control awsm-grid-list-item awsm-grid-list-item-3631\" data-info=\"3631\">\n\t\t\t\t\t\t<figure>\n\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"1000\" src=\"https:\/\/sfb1436.de\/wp-content\/uploads\/2022\/05\/20210526-350-PingAn-YuanXiang-800x1000.jpg\" class=\"attachment-awsm_team size-awsm_team wp-post-image\" alt=\"SFB 1436 Mitglied PingAn YuanXiang\" \/>\t\t\t\t\t\t\t<figcaption>\n\t\t\t\t\t\t\t\t<div class=\"awsm-personal-info\"><span><\/span><h3>Dr. Pingan Yuanxiang<\/h3><\/div>\t\t\t\t\t\t\t<\/figcaption>\n\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<div class=\"awsm-grid-expander style-1\">\n\t\t\t\t\t\t<div id=\"awsm-member-info-25026-29426\"  class=\"awsm-grid-expander style-1\">\n\t\t\t\t<div class=\"awsm-detailed-info\" id=\"awsm-grid-content-29426\">\n\t\t\t\t\t<div class=\"awsm-details\">\n\t\t\t\t\t\t<div class=\"awsm-personal-details\">\n\t\t\t\t\t\t\t<div class=\"awsm-content-scrollbar\">\n\t\t\t\t\t\t\t\t<span><\/span><h2>Patrick Kraus<\/h2>\n<p class=\"wp-block-paragraph\">coming soon<\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"awsm-personal-contact-info\">\n\t\t\t\t\t   <div class=\"awsm-contact-details\"><p><span>Institut:<\/span><a href=\"https:\/\/www.lin-magdeburg.de\/\" target=\"_blank\">Leibniz-Institut f\u00fcr Neurobiologie (LIN) Magdeburg<\/a><\/p><p><span>Projekt:<\/span><a href=\"\/de\/projekte\/a02_die-bildung-von-gedaechtnisspuren-ueber-exzitations-transkriptionskopplung\/\" target=\"_blank\"><b>A02<\/b> Die Bildung von Ged\u00e4chtnisspuren \u00fcber Exzitations-Transkriptionskopplung<\/a><\/p><\/div><div class=\"awsm-social-icons\"><span><a href=\"mailto:patrick1.kraus@st.ovgu.de\"><i class=\"awsm-icon-mail\" aria-hidden=\"true\"><\/i><\/a><\/span><span><a href=\"https:\/\/www.lin-magdeburg.de\/forschung\/forschergruppe-neuroplastizitaet\" target=\"_blank\"><i class=\"awsm-icon-link\" aria-hidden=\"true\"><\/i><\/a><\/span><\/div>\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<div id=\"awsm-member-info-25026-3711\"  class=\"awsm-grid-expander style-1\">\n\t\t\t\t<div class=\"awsm-detailed-info\" id=\"awsm-grid-content-3711\">\n\t\t\t\t\t<div class=\"awsm-details\">\n\t\t\t\t\t\t<div class=\"awsm-personal-details\">\n\t\t\t\t\t\t\t<div class=\"awsm-content-scrollbar\">\n\t\t\t\t\t\t\t\t<span><\/span><h2>Dr. Anja Oelschlegel<\/h2>\n<p class=\"wp-block-paragraph\">coming soon<\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"awsm-personal-contact-info\">\n\t\t\t\t\t   <div class=\"awsm-contact-details\"><p><span>Institut:<\/span><a href=\"https:\/\/www.lin-magdeburg.de\/\" target=\"_blank\">Leibniz-Institut f\u00fcr Neurobiologie (LIN) Magdeburg<\/a><\/p><p><span>Projekt:<\/span><a href=\"\/de\/projekte\/a02_die-bildung-von-gedaechtnisspuren-ueber-exzitations-transkriptionskopplung\/\" target=\"_blank\"><b>A02<\/b> Die Bildung von Ged\u00e4chtnisspuren \u00fcber Exzitations-Transkriptionskopplung<\/a><\/p><p><span>Projekt:<\/span><a href=\"https:\/\/sfb1436.de\/de\/projekte\/a04_verbesserung-der-kognitiven-leistungsfaehigkeit-durch-das-anti-aging-hormon-klotho\/\" target=\"_blank\"><b>A04<\/b> Verbesserung der kognitiven Leistungsf\u00e4higkeit durch das Anti-Aging Hormon Klotho \u2013 Von molekularen Mechanismen zu Interventionen<\/a><\/p><\/div><div class=\"awsm-social-icons\"><span><a href=\"mailto:aoelschl@lin-magdeburg.de\"><i class=\"awsm-icon-mail\" aria-hidden=\"true\"><\/i><\/a><\/span><span><a href=\"https:\/\/www.lin-magdeburg.de\/forschung\/forschergruppe-neuroplastizitaet\" target=\"_blank\"><i class=\"awsm-icon-link\" aria-hidden=\"true\"><\/i><\/a><\/span><\/div>\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<div id=\"awsm-member-info-25026-3719\"  class=\"awsm-grid-expander style-1\">\n\t\t\t\t<div class=\"awsm-detailed-info\" id=\"awsm-grid-content-3719\">\n\t\t\t\t\t<div class=\"awsm-details\">\n\t\t\t\t\t\t<div class=\"awsm-personal-details\">\n\t\t\t\t\t\t\t<div class=\"awsm-content-scrollbar\">\n\t\t\t\t\t\t\t\t<span><\/span><h2>Dr. Rajeev Raman<\/h2>\n<p class=\"wp-block-paragraph\">Rajeev Raman stammt urspr\u00fcnglich aus Ranchi, Jharkhand, Indien. Er promovierte am Center for Cellular and Molecular Biology (CCMB), Hyderabad, Indien. Seit Januar 2016 arbeitet er als wissenschaftlicher Mitarbeiter bei NPlast, (Dr. Michael Kreutz Group, LIN, Magdeburg). Rajeev bringt viel Erfahrung und Kompetenz in der Proteinbiochemie in seine Arbeit ein.<\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"awsm-personal-contact-info\">\n\t\t\t\t\t   <div class=\"awsm-contact-details\"><p><span>Institut:<\/span><a href=\"https:\/\/www.lin-magdeburg.de\/\" target=\"_blank\">Leibniz-Institut f\u00fcr Neurobiologie (LIN) Magdeburg<\/a><\/p><p><span>Projekt:<\/span><a href=\"\/de\/projekte\/a02_die-bildung-von-gedaechtnisspuren-ueber-exzitations-transkriptionskopplung\/\" target=\"_blank\"><b>A02<\/b> Die Bildung von Ged\u00e4chtnisspuren \u00fcber Exzitations-Transkriptionskopplung<\/a><\/p><p><span>Projekt:<\/span><a href=\"\/de\/projekte\/a04_verbesserung-der-kognitiven-leistungsfaehigkeit-durch-das-anti-aging-hormon-klotho\/\" target=\"_blank\"><b>A04<\/b> Verbesserung der kognitiven Leistungsf\u00e4higkeit durch das Anti-Aging Hormon Klotho - Von molekularen Mechanismen zu Interventionen<\/a><\/p><p><span>Projekt:<\/span><a href=\"https:\/\/sfb1436.de\/de\/projekte\/z01-funktionelle-analyse-von-neuronalen-netzwerken-in-nagern\/\" target=\"_blank\"><b>Z01<\/b> Funktionelle Analyse von neuronalen Netzwerken in Nagern<\/a><\/p><\/div><div class=\"awsm-social-icons\"><span><a href=\"mailto:Rajeev.Raman@lin-magdeburg.de\"><i class=\"awsm-icon-mail\" aria-hidden=\"true\"><\/i><\/a><\/span><span><a href=\"https:\/\/www.lin-magdeburg.de\/forschung\/forschergruppe-neuroplastizitaet\" target=\"_blank\"><i class=\"awsm-icon-link\" aria-hidden=\"true\"><\/i><\/a><\/span><\/div>\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<div id=\"awsm-member-info-25026-3726\"  class=\"awsm-grid-expander style-1\">\n\t\t\t\t<div class=\"awsm-detailed-info\" id=\"awsm-grid-content-3726\">\n\t\t\t\t\t<div class=\"awsm-details\">\n\t\t\t\t\t\t<div class=\"awsm-personal-details\">\n\t\t\t\t\t\t\t<div class=\"awsm-content-scrollbar\">\n\t\t\t\t\t\t\t\t<span><\/span><h2>Sebastian Samer<\/h2>\n<p class=\"wp-block-paragraph\">coming soon<\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"awsm-personal-contact-info\">\n\t\t\t\t\t   <div class=\"awsm-contact-details\"><p><span>Institut:<\/span><a href=\"https:\/\/www.lin-magdeburg.de\/\" target=\"_blank\">Leibniz-Institut f\u00fcr Neurobiologie (LIN) Magdeburg<\/a><\/p><p><span>Projekt:<\/span><a href=\"\/de\/projekte\/a02_die-bildung-von-gedaechtnisspuren-ueber-exzitations-transkriptionskopplung\/\" target=\"_blank\"><b>A02<\/b> Die Bildung von Ged\u00e4chtnisspuren \u00fcber Exzitations-Transkriptionskopplung<\/a><\/p><\/div><div class=\"awsm-social-icons\"><span><a href=\"mailto:sebastian.samer@lin-magdeburg.de\"><i class=\"awsm-icon-mail\" aria-hidden=\"true\"><\/i><\/a><\/span><span><a href=\"https:\/\/www.lin-magdeburg.de\/forschung\/forschergruppe-neuroplastizitaet\" target=\"_blank\"><i class=\"awsm-icon-link\" aria-hidden=\"true\"><\/i><\/a><\/span><\/div>\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<div id=\"awsm-member-info-25026-3631\"  class=\"awsm-grid-expander style-1\">\n\t\t\t\t<div class=\"awsm-detailed-info\" id=\"awsm-grid-content-3631\">\n\t\t\t\t\t<div class=\"awsm-details\">\n\t\t\t\t\t\t<div class=\"awsm-personal-details\">\n\t\t\t\t\t\t\t<div class=\"awsm-content-scrollbar\">\n\t\t\t\t\t\t\t\t<span><\/span><h2>Dr. Pingan Yuanxiang<\/h2>\n<p class=\"wp-block-paragraph\">Mein Name ist PingAn YuanXiang und ich habe meinen Abschluss in Shanghai, China, gemacht. Im Hauptfach habe ich Neurobiologie an der Fudan-Universit\u00e4t in Shanghai studiert und 2012 meine Doktorarbeit abgeschlossen.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Seit 2013 arbeite ich als wissenschaftliche Mitarbeiterin bei Nplast am LIN. Mein Fachgebiet ist die Elektrophysiologie, einschlie\u00dflich Feldaufnahmen und Einzelzell-Patch-Clamp-Techniken, die ich auch mit zellbiologischen Techniken kombiniere. Mein Hauptinteresse gilt den molekularen Mechanismen der synaptischen Plastizit\u00e4t sowie den Alterungsregulatoren der Gehirnfunktionen.<\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"awsm-personal-contact-info\">\n\t\t\t\t\t   <div class=\"awsm-contact-details\"><p><span>Institut:<\/span><a href=\"https:\/\/www.lin-magdeburg.de\/\" target=\"_blank\">Leibniz-Institut f\u00fcr Neurobiologie (LIN) Magdeburg<\/a><\/p><p><span>Projekt:<\/span><a href=\"\/de\/projekte\/a02_die-bildung-von-gedaechtnisspuren-ueber-exzitations-transkriptionskopplung\/\" target=\"_blank\"><b>A02<\/b> Die Bildung von Ged\u00e4chtnisspuren \u00fcber Exzitations-Transkriptionskopplung<\/a><\/p><p><span>Projekt:<\/span><a href=\"https:\/\/sfb1436.de\/de\/projekte\/a04_verbesserung-der-kognitiven-leistungsfaehigkeit-durch-das-anti-aging-hormon-klotho\/\" target=\"_blank\"><b>A04<\/b> Verbesserung der kognitiven Leistungsf\u00e4higkeit durch das Anti-Aging Hormon Klotho \u2013 Von molekularen Mechanismen zu Interventionen<\/a><\/p><p><span>Projekt:<\/span><a href=\"https:\/\/sfb1436.de\/de\/projekte\/z01-funktionelle-analyse-von-neuronalen-netzwerken-in-nagern\/\" target=\"_blank\"><b>Z01<\/b> Funktionelle Analyse von neuronalen Netzwerken in Nagern<\/a><\/p><\/div><div class=\"awsm-social-icons\"><span><a href=\"mailto:Pingan.Yuanxiang@lin-magdeburg.de\"><i class=\"awsm-icon-mail\" aria-hidden=\"true\"><\/i><\/a><\/span><span><a href=\"https:\/\/www.lin-magdeburg.de\/forschung\/forschergruppe-neuroplastizitaet\" target=\"_blank\"><i class=\"awsm-icon-link\" aria-hidden=\"true\"><\/i><\/a><\/span><\/div>\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t<\/div>\n\t<\/div>\n\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns alignwide justify-content-center is-layout-flex wp-container-core-columns-is-layout-cda6d148 wp-block-columns-is-layout-flex\" id=\"project-a02\" style=\"margin-top:0px;margin-bottom:0px;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<div class=\"wp-block-columns are-vertically-aligned-top is-layout-flex wp-container-core-columns-is-layout-f56f613f wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-top is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<h3 class=\"wp-block-heading has-white-color has-secondary-background-color has-text-color has-background has-medium-font-size\" id=\"besteht-ein-zusammenhang-zwischen-der-hirnaktivitat-und-der-ecm-zusammensetzung\"><br>Was sind synapto-nukle\u00e4re Proteinbotenstoffe?<br><br><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\" id=\"besteht-ein-zusammenhang-zwischen-der-hirnaktivitat-und-der-ecm-zusammensetzung\">Neurone exprimieren mehr Gene als andere Zelltypen und es erscheint unwahrscheinlich, dass allein eine Signal\u00fcbertragung durch Ca<sup>2+<\/sup> gen\u00fcgt, um die zahlreichen extrazellul\u00e4ren Stimuli in kontrollierte genomische Antworten zu \u00fcbersetzen. M\u00f6gliche weitere Kandidaten f\u00fcr die Ver- und Entschl\u00fcsselung von Signalen an deren Entstehungsorten bzw. im Zellkern als ihrem Zielort sind synapto-nukle\u00e4re Proteinbotenstoffe. Diese translozieren nach entsprechendem Stimulus von Synapsen zum Zellkern, wo sie \u00fcber die Interaktion mit anderen Molek\u00fclen sehr gezielt Aspekte der Genexpression regulieren k\u00f6nnen.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-top is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<h3 class=\"wp-block-heading has-white-color has-secondary-background-color has-text-color has-background has-medium-font-size\" id=\"matrix-variabilitat-und-kognitive-flexibigenetische-variabilitat-in-ecm-kodierenden-genen\">Warum ist die Kopplung von Erregung und Transkription wichtig f\u00fcr die Bildung von Engrammen und die Ged\u00e4chtniskonsolidierung?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">In einem neuronalen Netzwerk variiert die Aktivit\u00e4t exzitatorischer Synapsen zwischen den beteiligten Neuronen. Die intrinsische Erregbarkeit eines Neurons bezeichnet seine Neigung, Aktionspotentiale auf einen definierten Stimulus hin auszul\u00f6sen. Die <em>de novo<\/em> Transkription von Genen ist grundlegend f\u00fcr die Bildung von Langzeitged\u00e4chtnis, wobei sie an der&nbsp; Ged\u00e4chtniskonsolidierung beteiligt ist. Die biologischen Mechanismen dieser Konsolidierung beinhalten initial eine schnelle Phase der Genexpression, bekannt als molekulare Konsolidierung. W\u00e4hrend dieses Konzept allgemein anerkannt ist, sind die zugrunde liegenden neurobiologischen Mechanism noch unklar. Ein paradigmatischer Transkriptionsfaktor, dessen Aktivierung mit der Bildung von Langzeitged\u00e4chtnis verkn\u00fcpt ist, ist CREB. Mehrere Studien haben CREB als Konvergenzpunkt f\u00fcr Signalwege und Mechanismen sowohl w\u00e4hrend der St\u00e4rkung von Synapsen als auch der Ged\u00e4chtnisbildung identifizert.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns alignfull are-vertically-aligned-center has-white-color has-secondary-background-color has-text-color has-background is-layout-flex wp-container-core-columns-is-layout-cda6d148 wp-block-columns-is-layout-flex\" id=\"the-goals-of-our-project\" style=\"margin-top:0px;margin-bottom:0px;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\">\n<h2 class=\"wp-block-heading has-text-align-right\" id=\"the-goals-of-our-project-1\"><strong>Die Ziele unseres Projekts<\/strong><\/h2>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center has-project-c-background-color has-background is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:50px;padding-right:150px;padding-bottom:50px;padding-left:150px\">\n<p class=\"wp-block-paragraph\">Im Rahmen dieses SFBs ist es bedeutsam, dass die Regulierung neuronaler Erregbarkeit einen potenziellen molekularen Mechanismus darstellt, welcher der CREB-abh\u00e4ngigen neuronalen Selektion zugrunde liegt. Fr\u00fchere Arbeiten haben gezeigt, dass Neurone mit erh\u00f6htem CREB bevorzugt in Ged\u00e4chtnisspuren rekrutiert werden. CREB-vermittelte \u00c4nderungen in der neuronalen Erregbarkeit gew\u00e4hrleisten eine effektive Verkn\u00fcpfung zeitnaher Ereignisse und unterst\u00fctzen die funktionelle Einrichtuung von Zellverb\u00e4nden w\u00e4hrend der Ged\u00e4chtnis Konsolidierungsphase. Ged\u00e4chtnisbildung h\u00e4ngt dabei sowohl von Eingangs-spezifischen Modifikationen synaptischer St\u00e4rke als auch von zell-spezifisch gesteigerter Erregbarkeit ab. &nbsp;Letztere wie auch die Zunahme an plastischen Synapsen durch CREB k\u00f6nnten die Wahrscheinlichkeit erh\u00f6hen, dass Neurone mit hohem CREB-Spiegel in Ged\u00e4chtnisspuren integriert werden,&nbsp; und an der molekularen Konsolidierung beteiligt sind.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Wir werden der Hypothese nachgehen, dass der Proteintransport von der Synapse zum Zellkern CREB Transkritionskomplexe stabilisert und daher in die zellul\u00e4re Zuordnung und\/oder molekulare Konsolidierung von Ged\u00e4chtnis involviert ist. Ein zweites Ziel ist, die molekularen Prinzipien der Jacob-induzierten Kopplung von Erregung und Transkription als eine neurale Resource in pyramidalen CA1 Neuronen zu nutzen. Dazu werden transgene Mausmodelle und virale Interventionen kombiniert, sowie die Analyse synaptischer Funktion, neuraler Schaltkreise und Verhalten experimentell verkn\u00fcpft, mit dem ultimativen Ziel der Mobilisierung und Verst\u00e4rkung von Resourcen und der Freisetzung von versteckten Potenzialen. &nbsp;&nbsp;&nbsp;<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns alignfull gap-none is-layout-flex wp-container-core-columns-is-layout-cda6d148 wp-block-columns-is-layout-flex\" style=\"margin-top:0px;margin-bottom:0px;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<div class=\"wp-block-cover is-light is-repeated\"><div class=\"wp-block-cover__image-background wp-image-12591 is-repeated\" style=\"background-position:64% 59%;background-image:url(https:\/\/sfb1436.de\/wp-content\/uploads\/2022\/05\/senior-man-playing-puzzle.png)\"><\/div><span aria-hidden=\"true\" class=\"wp-block-cover__background has-background-dim-20 has-background-dim\"><\/span><div class=\"wp-block-cover__inner-container is-layout-flow wp-block-cover-is-layout-flow\">\n<p class=\"has-text-align-center has-large-font-size wp-block-paragraph\"><\/p>\n<\/div><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<div class=\"wp-block-cover is-light\"><img loading=\"lazy\" decoding=\"async\" width=\"1900\" height=\"1069\" class=\"wp-block-cover__image-background wp-image-168\" alt=\"EEG Messung am Gehirn von Proanden\" src=\"https:\/\/sfb1436.de\/wp-content\/uploads\/2021\/11\/news-beitrag3.jpg\" data-object-fit=\"cover\"\/><span aria-hidden=\"true\" class=\"wp-block-cover__background has-background-dim-0 has-background-dim\"><\/span><div class=\"wp-block-cover__inner-container is-layout-flow wp-block-cover-is-layout-flow\">\n<p class=\"has-text-align-center has-large-font-size wp-block-paragraph\"><\/p>\n<\/div><\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns alignfull is-layout-flex wp-container-core-columns-is-layout-dca53f0c wp-block-columns-is-layout-flex\" id=\"publications\" style=\"margin-top:0px;margin-bottom:0px\">\n<div class=\"wp-block-column has-project-c-background-color has-background is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:100%\">\n<section class=\"wp-block-group alignfull is-layout-flow wp-block-group-is-layout-flow\" style=\"padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<div class=\"wp-block-columns alignfull has-project-c-background-color has-background is-layout-flex wp-container-core-columns-is-layout-44579ee7 wp-block-columns-is-layout-flex\" style=\"margin-top:0px;margin-bottom:0px;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h2 class=\"wp-block-heading has-text-align-center has-white-color has-text-color\" id=\"publikationen-des-projektes-a02\"><strong>Publikationen des Projektes A02<\/strong><\/h2>\n\n\n\n\t\t\t<div class=\"wp-block-uagb-post-carousel uagb-post-grid project-slider uagb-post__image-position-top uagb-post__image-disabled uagb-block-bcf51a9c     uagb-post__arrow-outside uagb-slick-carousel uagb-post__items uagb-post__columns-3 is-carousel uagb-post__columns-tablet-2 uagb-post__columns-mobile-1\" data-total=\"2\" style=\"\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t<article class=\"uagb-post__inner-wrap\">\t\t\t\t\t\t\t\t<h4 class=\"uagb-post__title uagb-post__text\">\n\t\t\t\t<a href=\"https:\/\/doi.org\/10.1038\/s41582-026-01189-9\" target=\"_blank\" rel=\"bookmark noopener noreferrer\">Maintaining and regaining episodic memory in Alzheimer disease: a circuit-based perspective<\/a>\n\t\t\t<\/h4>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t\t<time datetime=\"2026-03-17T10:15:03+01:00\" class=\"uagb-post__date\">\n\t\t\t\t<span class=\"dashicons-calendar dashicons\"><\/span>\t\t\t\t\t17.03.2026\t\t\t\t<\/time>\n\t\t\t\t\t\t\t<div class=\"uagb-post__text\">\n\t\t\t\t\t<span class='uagb-post__taxonomy'>\n\t\t\t\t\t\t<span class=\"dashicons-tag dashicons\"><\/span>\t\t\t\t\t\t<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a02-de\/\">A02<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a04-de\/\">A04<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/b02-de\/\">B02<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/z01-de\/\">Z01<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/z03-de\/\">Z03<\/a>\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class='uagb-post__text uagb-post__excerpt'>\n\t\t\t\t\t<p>Emrah D\u00fczel &amp; Michael R. Kreutz <span class=\"excerpt-magazin\">Nature Reviews Neurology (2026)<\/span><\/p>\n<\/span>\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<article class=\"uagb-post__inner-wrap\">\t\t\t\t\t\t\t\t<h4 class=\"uagb-post__title uagb-post__text\">\n\t\t\t\t<a href=\"https:\/\/doi.org\/10.1002\/glia.24539\" target=\"_blank\" rel=\"bookmark noopener noreferrer\">Astrocytic uptake of posttranslationally modified amyloid-\u03b2 leads to endolysosomal system disruption and induction of pro-inflammatory signaling<\/a>\n\t\t\t<\/h4>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t\t<time datetime=\"2024-04-17T10:31:39+02:00\" class=\"uagb-post__date\">\n\t\t\t\t<span class=\"dashicons-calendar dashicons\"><\/span>\t\t\t\t\t17.04.2024\t\t\t\t<\/time>\n\t\t\t\t\t\t\t<div class=\"uagb-post__text\">\n\t\t\t\t\t<span class='uagb-post__taxonomy'>\n\t\t\t\t\t\t<span class=\"dashicons-tag dashicons\"><\/span>\t\t\t\t\t\t<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a02-de\/\">A02<\/a>\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class='uagb-post__text uagb-post__excerpt'>\n\t\t\t\t\t<p>Wirth S,\u00a0Schl\u00f6\u00dfer A, Beiersdorfer A, Schweizer M, Lohr C,\u00a0Grochowska KM <span class=\"excerpt-magazin\">Glia (2024)<\/span><\/p>\n<\/span>\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<article class=\"uagb-post__inner-wrap\">\t\t\t\t\t\t\t\t<h4 class=\"uagb-post__title uagb-post__text\">\n\t\t\t\t<a href=\"https:\/\/doi.org\/10.1016\/j.neuron.2023.12.016\" target=\"_blank\" rel=\"bookmark noopener noreferrer\">A septal to ventral tegmental area circuit drives exploratory behaviour<\/a>\n\t\t\t<\/h4>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t\t<time datetime=\"2024-02-02T10:27:58+01:00\" class=\"uagb-post__date\">\n\t\t\t\t<span class=\"dashicons-calendar dashicons\"><\/span>\t\t\t\t\t02.02.2024\t\t\t\t<\/time>\n\t\t\t\t\t\t\t<div class=\"uagb-post__text\">\n\t\t\t\t\t<span class='uagb-post__taxonomy'>\n\t\t\t\t\t\t<span class=\"dashicons-tag dashicons\"><\/span>\t\t\t\t\t\t<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a02-de\/\">A02<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a03-de\/\">A03<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a04-de\/\">A04<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/b06-de\/\">B06<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/z01-de\/\">Z01<\/a>\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class='uagb-post__text uagb-post__excerpt'>\n\t\t\t\t\t<p>Mocellin P, Barnstedt O,Luxem K, Kaneko H, Karpova A, Henschke J, Dal\u00fcgge D, Fuhrmann F, Pakan JMP, Kreutz MR, MikulovicS, and Remy S <span class=\"excerpt-magazin\">Neuron (2024)<\/span><\/p>\n<\/span>\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<article class=\"uagb-post__inner-wrap\">\t\t\t\t\t\t\t\t<h4 class=\"uagb-post__title uagb-post__text\">\n\t\t\t\t<a href=\"https:\/\/doi.org\/10.1016\/j.celrep.2023.112998\" target=\"_blank\" rel=\"bookmark noopener noreferrer\">Chaperone-mediated autophagy in neuronal dendrites utilizes activity-dependent lysosomal exocytosis for protein disposal<\/a>\n\t\t\t<\/h4>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t\t<time datetime=\"2023-08-29T14:30:25+02:00\" class=\"uagb-post__date\">\n\t\t\t\t<span class=\"dashicons-calendar dashicons\"><\/span>\t\t\t\t\t29.08.2023\t\t\t\t<\/time>\n\t\t\t\t\t\t\t<div class=\"uagb-post__text\">\n\t\t\t\t\t<span class='uagb-post__taxonomy'>\n\t\t\t\t\t\t<span class=\"dashicons-tag dashicons\"><\/span>\t\t\t\t\t\t<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a02-de\/\">A02<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a04-de\/\">A04<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/z01-de\/\">Z01<\/a>\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class='uagb-post__text uagb-post__excerpt'>\n\t\t\t\t\t<p>Grochowska KM, Sperveslage M, Raman R, Failla AV, G\u0142\u00f3w D, Schulze C, Laprell L, Fehse B, Kreutz MR <span class=\"excerpt-magazin\">Cell Rep (2023)<\/span><\/p>\n<\/span>\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<article class=\"uagb-post__inner-wrap\">\t\t\t\t\t\t\t\t<h4 class=\"uagb-post__title uagb-post__text\">\n\t\t\t\t<a href=\"https:\/\/doi.org\/10.1007\/s00018-023-04876-8\" target=\"_blank\" rel=\"bookmark noopener noreferrer\">Integration of nuclear Ca2+\u00a0transients and subnuclear protein shuttling provides a novel mechanism for the regulation of CREB-dependent gene expression<\/a>\n\t\t\t<\/h4>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t\t<time datetime=\"2023-07-25T15:28:35+02:00\" class=\"uagb-post__date\">\n\t\t\t\t<span class=\"dashicons-calendar dashicons\"><\/span>\t\t\t\t\t25.07.2023\t\t\t\t<\/time>\n\t\t\t\t\t\t\t<div class=\"uagb-post__text\">\n\t\t\t\t\t<span class='uagb-post__taxonomy'>\n\t\t\t\t\t\t<span class=\"dashicons-tag dashicons\"><\/span>\t\t\t\t\t\t<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a02-de\/\">A02<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a04-de\/\">A04<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/z01-de\/\">Z01<\/a>\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class='uagb-post__text uagb-post__excerpt'>\n\t\t\t\t\t<p>Karpova A, Samer S, Turacak R, Yuanxiang P, Kreutz MR.&nbsp; <span class=\"excerpt-magazin\">Cell Mol Life Sci (2023)<\/span><\/p>\n<\/span>\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<article class=\"uagb-post__inner-wrap\">\t\t\t\t\t\t\t\t<h4 class=\"uagb-post__title uagb-post__text\">\n\t\t\t\t<a href=\"https:\/\/doi.org\/10.1016\/j.celrep.2023.112692\" target=\"_blank\" rel=\"bookmark noopener noreferrer\">Golgi satellites are essential for polysialylation of NCAM and expression of LTP at distal synapses<\/a>\n\t\t\t<\/h4>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t\t<time datetime=\"2023-07-25T13:50:13+02:00\" class=\"uagb-post__date\">\n\t\t\t\t<span class=\"dashicons-calendar dashicons\"><\/span>\t\t\t\t\t25.07.2023\t\t\t\t<\/time>\n\t\t\t\t\t\t\t<div class=\"uagb-post__text\">\n\t\t\t\t\t<span class='uagb-post__taxonomy'>\n\t\t\t\t\t\t<span class=\"dashicons-tag dashicons\"><\/span>\t\t\t\t\t\t<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a02-de\/\">A02<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a04-de\/\">A04<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a05-de\/\">A05<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/z01-de\/\">Z01<\/a>\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class='uagb-post__text uagb-post__excerpt'>\n\t\t\t\t\t<p>Andres-Alonso M, Borgmeyer M, Mirzapourdelavar H, Lormann J, Klein K, Schweizer M, Hoffmeister-Ullerich S, Oelschlegel AM, Dityatev A, Kreutz MR <span class=\"excerpt-magazin\">Cell Rep (2023)<\/span><\/p>\n<\/span>\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<article class=\"uagb-post__inner-wrap\">\t\t\t\t\t\t\t\t<h4 class=\"uagb-post__title uagb-post__text\">\n\t\t\t\t<a href=\"https:\/\/doi.org\/10.1016\/j.mcn.2023.103854\" target=\"_blank\" rel=\"bookmark noopener noreferrer\">Protein transport from pre- and postsynapse to the nucleus: Mechanisms and functional implications<\/a>\n\t\t\t<\/h4>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t\t<time datetime=\"2023-06-14T14:35:01+02:00\" class=\"uagb-post__date\">\n\t\t\t\t<span class=\"dashicons-calendar dashicons\"><\/span>\t\t\t\t\t14.06.2023\t\t\t\t<\/time>\n\t\t\t\t\t\t\t<div class=\"uagb-post__text\">\n\t\t\t\t\t<span class='uagb-post__taxonomy'>\n\t\t\t\t\t\t<span class=\"dashicons-tag dashicons\"><\/span>\t\t\t\t\t\t<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a02-de\/\">A02<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a04-de\/\">A04<\/a>\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class='uagb-post__text uagb-post__excerpt'>\n\t\t\t\t\t<p>Maria Andres-Alonso, Katarzyna M Grochowska, Eckart D Gundelfinger, Anna Karpova, Michael R Kreutz <span class=\"excerpt-magazin\">Mol Cell Neurosci (2023)<\/span><\/p>\n<\/span>\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<article class=\"uagb-post__inner-wrap\">\t\t\t\t\t\t\t\t<h4 class=\"uagb-post__title uagb-post__text\">\n\t\t\t\t<a href=\"https:\/\/doi.org\/10.1016\/j.pep.2022.106057\" target=\"_blank\" rel=\"bookmark noopener noreferrer\">One-step purification of tag free and soluble lamin B1 from an E. coli bacterial expression system<\/a>\n\t\t\t<\/h4>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t\t<time datetime=\"2023-05-16T14:44:05+02:00\" class=\"uagb-post__date\">\n\t\t\t\t<span class=\"dashicons-calendar dashicons\"><\/span>\t\t\t\t\t16.05.2023\t\t\t\t<\/time>\n\t\t\t\t\t\t\t<div class=\"uagb-post__text\">\n\t\t\t\t\t<span class='uagb-post__taxonomy'>\n\t\t\t\t\t\t<span class=\"dashicons-tag dashicons\"><\/span>\t\t\t\t\t\t<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a02-de\/\">A02<\/a>\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class='uagb-post__text uagb-post__excerpt'>\n\t\t\t\t\t<p>Raman R, Karpova A, Kreutz MR <span class=\"excerpt-magazin\">Protein Expr Purif (2022)<\/span><\/p>\n<\/span>\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<article class=\"uagb-post__inner-wrap\">\t\t\t\t\t\t\t\t<h4 class=\"uagb-post__title uagb-post__text\">\n\t\t\t\t<a href=\"https:\/\/doi.org\/10.1186\/s13041-023-01012-2\" target=\"_blank\" rel=\"bookmark noopener noreferrer\">A Jacob\/nsmf gene knockout does not protect against acute hypoxia- and NMDA-induced excitotoxic cell death<\/a>\n\t\t\t<\/h4>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t\t<time datetime=\"2023-02-11T14:09:04+01:00\" class=\"uagb-post__date\">\n\t\t\t\t<span class=\"dashicons-calendar dashicons\"><\/span>\t\t\t\t\t11.02.2023\t\t\t\t<\/time>\n\t\t\t\t\t\t\t<div class=\"uagb-post__text\">\n\t\t\t\t\t<span class='uagb-post__taxonomy'>\n\t\t\t\t\t\t<span class=\"dashicons-tag dashicons\"><\/span>\t\t\t\t\t\t<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a02-de\/\">A02<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a04-de\/\">A04<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/z01-de\/\">Z01<\/a>\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class='uagb-post__text uagb-post__excerpt'>\n\t\t\t\t\t<p>Guilherme M Gomes, Julia B\u00e4r, Anna Karpova, Michael R Kreutz <span class=\"excerpt-magazin\">Mol Brain (2023)<\/span><\/p>\n<\/span>\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<article class=\"uagb-post__inner-wrap\">\t\t\t\t\t\t\t\t<h4 class=\"uagb-post__title uagb-post__text\">\n\t\t\t\t<a href=\"https:\/\/doi.org\/10.15252\/embj.2022112453\" target=\"_blank\" rel=\"bookmark noopener noreferrer\">Jacob-induced transcriptional inactivation of CREB promotes A\u03b2-induced synapse loss in Alzheimer&#8217;s disease<\/a>\n\t\t\t<\/h4>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t\t<time datetime=\"2023-01-03T17:15:59+01:00\" class=\"uagb-post__date\">\n\t\t\t\t<span class=\"dashicons-calendar dashicons\"><\/span>\t\t\t\t\t03.01.2023\t\t\t\t<\/time>\n\t\t\t\t\t\t\t<div class=\"uagb-post__text\">\n\t\t\t\t\t<span class='uagb-post__taxonomy'>\n\t\t\t\t\t\t<span class=\"dashicons-tag dashicons\"><\/span>\t\t\t\t\t\t<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a02-de\/\">A02<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a03-de\/\">A03<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a04-de\/\">A04<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/z01-de\/\">Z01<\/a>\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class='uagb-post__text uagb-post__excerpt'>\n\t\t\t\t\t<p>K. M Grochowska, G. M Gomes, R. Raman, R. Kaushik, L. Sosulina, H. Kaneko, A. M Oelschlegel, P. Yuanxiang, I. Reyes-Resina, G. Bayraktar, S. Samer, C. Spilker, M. S Woo, M. Morawski, J. Goldschmidt,&nbsp;M. A Friese, S. Rossner,&nbsp;G. Navarro, S&#8230;.<\/span>\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<article class=\"uagb-post__inner-wrap\">\t\t\t\t\t\t\t\t<h4 class=\"uagb-post__title uagb-post__text\">\n\t\t\t\t<a href=\"https:\/\/www.embopress.org\/doi\/full\/10.15252\/embj.2021110057\" target=\"_blank\" rel=\"bookmark noopener noreferrer\">The needs of a synapse &#8211; How local organelles serve synaptic proteostasis<\/a>\n\t\t\t<\/h4>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t\t<time datetime=\"2022-04-04T15:08:00+02:00\" class=\"uagb-post__date\">\n\t\t\t\t<span class=\"dashicons-calendar dashicons\"><\/span>\t\t\t\t\t04.04.2022\t\t\t\t<\/time>\n\t\t\t\t\t\t\t<div class=\"uagb-post__text\">\n\t\t\t\t\t<span class='uagb-post__taxonomy'>\n\t\t\t\t\t\t<span class=\"dashicons-tag dashicons\"><\/span>\t\t\t\t\t\t<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a02-de\/\">A02<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a04-de\/\">A04<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/z01-de\/\">Z01<\/a>\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class='uagb-post__text uagb-post__excerpt'>\n\t\t\t\t\t<p>Katarzyna M Grochowska, Maria Andres-Alonso, Anna Karpova, Michael R Kreutz <span class=\"excerpt-magazin\">EMBO J (2022)<\/span><\/p>\n<\/span>\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<article class=\"uagb-post__inner-wrap\">\t\t\t\t\t\t\t\t<h4 class=\"uagb-post__title uagb-post__text\">\n\t\t\t\t<a href=\"https:\/\/doi.org\/10.1186\/s40035-021-00277-8\" target=\"_blank\" rel=\"bookmark noopener noreferrer\">Neddylation-dependent protein degradation is a nexus between synaptic insulin resistance, neuroinflammation and Alzheimer&#8217;s disease<\/a>\n\t\t\t<\/h4>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t\t<time datetime=\"2022-01-06T10:58:00+01:00\" class=\"uagb-post__date\">\n\t\t\t\t<span class=\"dashicons-calendar dashicons\"><\/span>\t\t\t\t\t06.01.2022\t\t\t\t<\/time>\n\t\t\t\t\t\t\t<div class=\"uagb-post__text\">\n\t\t\t\t\t<span class='uagb-post__taxonomy'>\n\t\t\t\t\t\t<span class=\"dashicons-tag dashicons\"><\/span>\t\t\t\t\t\t<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a02-de\/\">A02<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a04-de\/\">A04<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/a05-de\/\">A05<\/a>,&nbsp;<a href=\"https:\/\/sfb1436.de\/de\/category\/publikation\/z01-de\/\">Z01<\/a>\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class='uagb-post__text uagb-post__excerpt'>\n\t\t\t\t\t<p>Alessandro Dario Confettura, Eleonora Cuboni, Mohamed Rafeet Ammar, Shaobo Jia, Guilherme M Gomes, PingAn Yuanxiang, Rajeev Raman, Tingting Li , Katarzyna M Grochowska, Robert Ahrends, Anna Karpova, Alexander Dityatev, Michael R Kreutz <span class=\"excerpt-magazin\">Translational Neurodegeneration (2022)<\/span><\/p>\n<\/span>\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-19fccbcd wp-block-buttons-is-layout-flex\" style=\"margin-top:40px;margin-bottom:0px\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link has-project-c-color has-white-background-color has-text-color has-background wp-element-button\" href=\"https:\/\/sfb1436.de\/de\/publikationen\/\">Alle Publikationen<\/a><\/div>\n\n\n\n<div class=\"wp-block-button is-style-outline is-style-outline--1\"><a class=\"wp-block-button__link has-white-color has-text-color wp-element-button\" href=\"https:\/\/sfb1436.de\/de\/projekte\/\">Alle Projekte<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Expression von Genen unterst\u00fctzt, die die Bildung von Ged\u00e4chtnisspuren f\u00f6rdern. Wir wollen uns Mechanismen von Exzitations-Transkriptionskopplung als neuronale Ressource zunutze machen, um die Ged\u00e4chtnisbildung zu f\u00f6rdern. Wir konnten bereits zeigen, dass Interventionen, die diesen Signalweg ver\u00e4ndern, die kognitive Leistungsf\u00e4higkeit verbessern. \u00dcbergeordnetes Ziel des Projekts ist aufbauend auf den entschl\u00fcsselten Mechanismen dem kognitiven Abbau im Alter [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":0,"parent":3279,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_crdt_document":"","_uag_custom_page_level_css":"","footnotes":""},"class_list":["post-6965","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Exzitations-Transkriptionskopplung - SFB1436<\/title>\n<meta name=\"description\" content=\"Expression von Genen unterst\u00fctzt, die die Bildung von Ged\u00e4chtnisspuren f\u00f6rdern. 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Wir wollen uns Mechanismen von Exzitations-Transkriptionskopplung als neuronale Ressource zunutze machen, um die Ged\u00e4chtnisbildung zu f\u00f6rdern. Wir konnten bereits zeigen, dass Interventionen, die diesen Signalweg ver\u00e4ndern, die kognitive Leistungsf\u00e4higkeit verbessern. \u00dcbergeordnetes Ziel des Projekts ist aufbauend auf den entschl\u00fcsselten Mechanismen dem kognitiven Abbau im Alter&hellip;","_links":{"self":[{"href":"https:\/\/sfb1436.de\/de\/wp-json\/wp\/v2\/pages\/6965","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sfb1436.de\/de\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sfb1436.de\/de\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sfb1436.de\/de\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/sfb1436.de\/de\/wp-json\/wp\/v2\/comments?post=6965"}],"version-history":[{"count":34,"href":"https:\/\/sfb1436.de\/de\/wp-json\/wp\/v2\/pages\/6965\/revisions"}],"predecessor-version":[{"id":27434,"href":"https:\/\/sfb1436.de\/de\/wp-json\/wp\/v2\/pages\/6965\/revisions\/27434"}],"up":[{"embeddable":true,"href":"https:\/\/sfb1436.de\/de\/wp-json\/wp\/v2\/pages\/3279"}],"wp:attachment":[{"href":"https:\/\/sfb1436.de\/de\/wp-json\/wp\/v2\/media?parent=6965"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}